Dermoid sinus and spinal malformations in a Yorkshire terrier: Diagnosis and follow‐up

Fatone, Gerardo; Brunetti, Arturo; Lamagna, Francesco; Potena, A.

doi:10.1111/j.1748-5827.1995.tb02877.x

Cited by 36 publications

(42 citation statements)

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“…In rare cases, a dermoid sinus can be associated with vertebral malformations, as in these cases presented here (Selcer and others 1984, Fatone and others 1995, Cornegliani and others 2001, Bowens and others 2005, Colon and others 2007, Tong and Simpson 2009). Spina bifida seems to be related to dermoid sinuses that reach the spinal canal (Fatone and others 1995, Pratt and others 2000, Bowens and others 2005, Colon and others 2007, Tong and Simpson 2009). This may be due to the interaction between neural crest, mesoderm (the embryological origin of the bone tissue) and the neuroectodermal neural tube that is required for normal development of the neuraxis.…”

Section: Discussionsupporting

confidence: 58%

“…Swedish vallhund is a multi‐purpose dog with short legs and a long body resembling Welsh corgis. Besides the ridgeback and its cross‐breeds, dermoid sinus has been reported in the English springer spaniel (Pratt and others 2000), the rottweiler (Bornard and others 2007), the Yorkshire terrier (Fatone and others 1995), the golden retriever (Cornegliani and others 2001), the boerboel (Penrith and others 1994), the Siberian husky (Cornegliani and Ghibaudo 1999), the shih tzu, the boxer (Selcer and others 1984), the chow chow (Booth 1998), the Great Pyrenees dog (Camacho and others 1995) and a Burmese cat (Tong and Simpson 2009).…”

Section: Discussionmentioning

confidence: 99%

“…Unfortunately, no studies evaluating the long‐term outcome of conservative therapy have been published. Dermoid sinuses can, however, be asymptomatic for months to years before becoming infected or inflamed (Selcer and others 1984, Marks and others 1993, Lambrechts 1996, Pratt and others 2000, Davies and others 2004) or can cause spinal cord compression due to debris accumulation (Fatone and others 1995) or cyst enlargement (Tong and Simpson 2009). Neurological abnormalities can also occur acutely because of trauma caused by pulling the protruding hair from the sinus in asymptomatic animals (Colon and others 2007).…”

Section: Discussionmentioning

confidence: 99%

“…A plug of hair may protrude from the sinus orifice, which is often surrounded by a whorl of hair. Neurological signs can occur if the defect extends to the spinal canal and becomes infected or inflamed (Selcer and others 1984, Fatone and others 1995, Pratt and others 2000, Cornegliani and others 2001).…”

Section: Introductionmentioning

confidence: 99%

“…A presumptive diagnosis can be made on the basis of history and clinical signs, but a fistulogram, a myelogram, computed tomography (CT) or magnetic resonance imaging (MRI) can confirm the diagnosis (Fatone and others 1995, Scott and others 2001, Rahal and others 2008).…”

Section: Introductionmentioning

confidence: 99%

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Dermoid sinus and spina bifida in three dogs and a cat

Kiviranta

Lappalainen²,

Hagner

et al. 2011

Journal of Small Animal Practice

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This case series describes four cases of concomitant dermoid sinus and spina bifida in a Chinese crested dog, two Swedish vallhunds and a Burmese cat. The diagnosis was confirmed by computed tomography, computed tomography fistulography and pathology. Two dogs that showed abnormalities during neurological examination underwent magnetic resonance imaging. One of them had imaging findings interpreted as syringohydromyelia. All the dogs underwent surgery and the outcome was considered good in all the cases. Based on clinical and pathological examination as well as diagnostic imaging findings, two of the dermoid sinuses were classified as type IV, and two of them showed a previously unreported type of dermoid sinus. This new type is suggested here as type VI.

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Section: Discussionsupporting

confidence: 58%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Dermoid sinus and spina bifida in three dogs and a cat

Kiviranta

Lappalainen²,

Hagner

et al. 2011

Journal of Small Animal Practice

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Comparison of inherited neural tube defects in companion animals and livestock

Zarzycki

Thomas

Mazrier

2020

Birth Defects Research

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Neural tube defects (NTDs) are congenital malformations resulting from the improper or incomplete closure of the neural tube during embryonic development. A number of similar malformations of the protective coverings surrounding the central nervous system are also often included under this umbrella term, which may not strictly fit this definition. A range of NTD phenotypes exist and have been reported in humans and a wide range of domestic and livestock species. In the veterinary literature, these include cases of anencephaly, encephalocele, dermoid sinus, spina bifida, and craniorachischisis. While environmental factors have a role, genetic predisposition may account for a significant part of the risk of NTDs in these animal cases. Studies of laboratory model species (fish, birds, amphibians, and rodents) have been instrumental in improving our understanding of the neurulation process. In mice, over 200 genes that may be involved in this process have been identified and variant phenotypes investigated. Like laboratory mouse models, domestic animals and livestock species display a wide range of NTD phenotypes. They remain, however, a largely underutilized population and could complement already established laboratory models. Here we review reports of NTDs in companion animals and livestock, and compare these to other animal species and human cases. We aim to highlight the potential of nonlaboratory animal models for mutation discovery as well as general insights into the mechanisms of neurulation and the development of NTDs.

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Open spina bifida characterisation in a dog foetus

Chen,

Su,

Sun

et al. 2023

Veterinary Medicine & Sci

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BackgroundOpen spina bifida is an uncommon malformation in animals, and there is a lack of imaging, clinical, and pathological characterisation of this condition in dogs.ObjectiveOpen spina bifida is rarely observed in animals due to high levels of perinatal mortality and frequent euthanasia. To the best of our knowledge, we present the first case of spina bifida in a dog was diagnosed in‐utero and then followed post‐partum.MethodsA 3‐year‐old Poodle was presented with twin pregnancy. Radiographic and ultrasonographic findings were suggestive of vertebral malformation and open spina bifida with myelomeningocele in one foetus. Conservative treatment was given but the puppy died 3 days after birth. Thereafter, anatomical and histopathological analysis of several organs was performed to characterise the disease.ResultsWhen the twins were born, one puppy had a linear dorsal midline cutaneous defect extending from the level of vertebrae L2–L6. R Radiographic examination showed several congenital vertebral malformations involving the thoracic segment, lumbar segment, sacrum and scapula. Histopathological examinations confirmed the presence of open spina bifida and identified additional abnormalities in several internal organs.ConclusionsThis case presents a complete characterisation of open spina bifida, before birth and after death, using imaging and histopathology techniques.

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Dermoid sinus and spinal malformations in a Yorkshire terrier: Diagnosis and follow‐up

Cited by 36 publications

References 1 publication

Dermoid sinus and spina bifida in three dogs and a cat

Dermoid sinus and spina bifida in three dogs and a cat

Comparison of inherited neural tube defects in companion animals and livestock

Open spina bifida characterisation in a dog foetus

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