Dermoscopy as an auxiliary tool in the differentiation of the main types of erythroderma due to dermatological disorders

Errichetti, Enzo; Piccirillo, Angelo; Stinco, Giuseppe

doi:10.1111/ijd.13322

Cited by 45 publications

(56 citation statements)

References 7 publications

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“…Focal whitish scales are sometimes visible, but they are always associated with the aforementioned “yellowish findings” [13, 26–28]. According to the disease stage, eczematous dermatitis may display some differences, with acute exudative lesions mainly showing yellow scale/crusts (“yellow clod sign”) and chronic and lichenified lesions predominantly displaying dotted vessels in a patchy distribution and scaling [1, 13, 29, 30]. …”

Section: Dermatoses Presenting With Erythematous-desquamative Patchesmentioning

confidence: 99%

“…Dermoscopy of erythrodermic psoriasis reveals a monomorphous pattern with diffusely distributed whitish scales and regularly arranged dotted/glomerular vessels on a fairly homogeneous reddish background [29, 126]. …”

Section: Erythrodermasmentioning

confidence: 99%

“…As for other types of eczematous dermatitis, the most important dermoscopic features of erythrodermic atopic dermatitis consist of yellowish scales/serocrusts and patchily distributed dotted vessels on a pinkish background; unspecific sparse whitish scales may also be seen [29]. …”

Section: Erythrodermasmentioning

confidence: 99%

“…The most characteristic dermoscopic finding of erythrodermic mycosis fungoides is represented by the combination of linear vessels (some of them having a spermatozoon-like shape) and dotted vessels over a whitish-pinkish background; unspecific sparse whitish scales are also visible [29]. …”

Section: Erythrodermasmentioning

confidence: 99%

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Dermoscopy in General Dermatology: A Practical Overview

Errichetti

Stinco

2016

Dermatol Ther (Heidelb)

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331

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Over the last few years, dermoscopy has been shown to be a useful tool in assisting the noninvasive diagnosis of various general dermatological disorders. In this article, we sought to provide an up-to-date practical overview on the use of dermoscopy in general dermatology by analysing the dermoscopic differential diagnosis of relatively common dermatological disorders grouped according to their clinical presentation, i.e. dermatoses presenting with erythematous-desquamative patches/plaques (plaque psoriasis, eczematous dermatitis, pityriasis rosea, mycosis fungoides and subacute cutaneous lupus erythematosus), papulosquamous/papulokeratotic dermatoses (lichen planus, pityriasis rosea, papulosquamous sarcoidosis, guttate psoriasis, pityriasis lichenoides chronica, classical pityriasis rubra pilaris, porokeratosis, lymphomatoid papulosis, papulosquamous chronic GVHD, parakeratosis variegata, Grover disease, Darier disease and BRAF-inhibitor-induced acantholytic dyskeratosis), facial inflammatory skin diseases (rosacea, seborrheic dermatitis, discoid lupus erythematosus, sarcoidosis, cutaneous leishmaniasis, lupus vulgaris, granuloma faciale and demodicidosis), acquired keratodermas (chronic hand eczema, palmar psoriasis, keratoderma due to mycosis fungoides, keratoderma resulting from pityriasis rubra pilaris, tinea manuum, palmar lichen planus and aquagenic palmar keratoderma), sclero-atrophic dermatoses (necrobiosis lipoidica, morphea and cutaneous lichen sclerosus), hypopigmented macular diseases (extragenital guttate lichen sclerosus, achromic pityriasis versicolor, guttate vitiligo, idiopathic guttate hypomelanosis, progressive macular hypomelanosis and postinflammatory hypopigmentations), hyperpigmented maculopapular diseases (pityriasis versicolor, lichen planus pigmentosus, Gougerot-Carteaud syndrome, Dowling-Degos disease, erythema ab igne, macular amyloidosis, lichen amyloidosus, friction melanosis, terra firma-forme dermatosis, urticaria pigmentosa and telangiectasia macularis eruptiva perstans), itchy papulonodular dermatoses (hypertrophic lichen planus, prurigo nodularis, nodular scabies and acquired perforating dermatosis), erythrodermas (due to psoriasis, atopic dermatitis, mycosis fungoides, pityriasis rubra pilaris and scabies), noninfectious balanitis (Zoon’s plasma cell balanitis, psoriatic balanitis, seborrheic dermatitis and non-specific balanitis) and erythroplasia of Queyrat, inflammatory cicatricial alopecias (scalp discoid lupus erythematosus, lichen planopilaris, frontal fibrosing alopecia and folliculitis decalvans), nonscarring alopecias (alopecia areata, trichotillomania, androgenetic alopecia and telogen effluvium) and scaling disorders of the scalp (tinea capitis, scalp psoriasis, seborrheic dermatitis and pityriasis amiantacea).

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Section: Dermatoses Presenting With Erythematous-desquamative Patchesmentioning

confidence: 99%

Section: Erythrodermasmentioning

confidence: 99%

Section: Erythrodermasmentioning

confidence: 99%

Section: Erythrodermasmentioning

confidence: 99%

See 2 more Smart Citations

Dermoscopy in General Dermatology: A Practical Overview

Errichetti

Stinco

2016

Dermatol Ther (Heidelb)

Self Cite

331

364

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show abstract

“…All subtypes of dermatitis are primarily characterized by dotted vessels in a patchy distribution and yellow serocrusts or scaling [22,23] . Depending on the stage of the disease, eczematous dermatitis displays some common characteristics: acute exudative lesions are characterized by yellow scale/crusts (-yellow clod sign‖) while chronic, lichenified lesions appear mainly with patchily distributed dotted vessels within the lesion [24][25][26] .…”

Section: Dermatitismentioning

confidence: 99%

Alternative uses of dermoscopy in general dermatology

Papakonstantinou

Raap

2017

J Surg Dermatol

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Abstract:Over the last few years, dermoscopy has been shown to be an effective diagnostic tool in assisting the noninvasive diagnosis not only of skin tumors but also of various general dermatological disorders. The use of dermoscopy has offered a new morphological dimension supporting the diagnosis and clinical follow-up of several dermatological conditions. Within the last years, dermoscopy is gaining ground in general dermatology as well. Among the large spectrum of skin infections, specific dermoscopic patterns have been described for common skin infections such as viral warts, molluscum contagiosum, scabies, and pediculosis, as well as for tinea nigra, tungiasis, and cutaneous larva migrans. Also, common skin disorders such as psoriasis, pityriasis rosea or lichen planus show characteristic dermoscopic patterns. The aim of this article is to provide an overview of the use of dermoscopy in general dermatology by analyzing the dermoscopic differential diagnosis of relatively common dermatological disorders grouped according to their clinical characteristics.

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Efficacy and Safety of Dupilumab in Patients With Erythrodermic Atopic Dermatitis

et al. 2023

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ImportanceErythrodermic atopic dermatitis (AD) is a severe AD subtype defined by extensive skin involvement, leading to complications and sometimes hospitalization.ObjectiveTo assess dupilumab’s efficacy and safety in patients with erythrodermic AD in clinical trials.Design, Setting, and ParticipantsThis post hoc analysis included patients enrolled in 6 multicenter, multinational, randomized, double-blind, placebo-controlled trials. Patients included in this analysis met erythrodermic AD criteria of 90% or greater body surface area (BSA) affected by AD and Global Individual Sign Score for erythema of 1 or higher. Data analyses for this post hoc analysis were conducted between March 5, 2019, and October 24, 2020.InterventionsDupilumab once weekly or every 2 weeks, or placebo, either as monotherapy or with concomitant topical corticosteroids (TCS).Main Outcomes and MeasuresEfficacy (BSA, Eczema Area and Severity Index [EASI] score, Peak Pruritus Numerical Rating Scale [PP-NRS] score), changes in serum biomarkers (thymus and activation-regulated chemokine, total immunoglobulin E, lactate dehydrogenase), and safety (incidence of adverse events) at week 16. Data were pooled within each regimen; monotherapy and concomitant TCS results are shown separately.ResultsOf 3075 randomized patients, 209 met criteria for erythrodermic AD at baseline, with the median age being 31 and 39 years in the monotherapy and concomitant TCS trials, respectively, similar to the overall populations (34 and 36 years, respectively); 71.3% (n = 97) and 74.0% (n = 54) of patients, respectively, were male (compared with 58.7% and 60.6% in the overall populations). In patients with erythrodermic AD, dupilumab once weekly and every 2 weeks vs placebo significantly improved percentage of BSA affected by AD (least squares mean percent change [SE]) with monotherapy (−42.0% [7.7%] and −39.9% [6.5%] vs −17.2% [11.0%]; P = .03) and concomitant TCS (−63.2% [6.7%] and −56.1% [9.1%] vs −14.5% [7.3%]; P &lt; .001); EASI score with monotherapy (−58.5% [9.0%] and −58.3% [7.9%] vs −22.3% [12.4%]; P = .004 and P = .003, respectively) and concomitant TCS (−78.9% [7.8%] and −70.6% [10.1%] vs 19.3% [8.2%]; P &lt; .001); and PP-NRS score in monotherapy (−45.9% [7.8%] and −33.9% [6.6%] vs −0.6% [9.4%]; P &lt; .001) and concomitant therapy (−53.0% [8.1%] and −55.7% [10.8%] vs −26.0% [8.8%]; P = .006 and P = .01, respectively). Nominally statistically significant improvement was seen as early as week 1 (EASI and PP-NRS scores with monotherapy). Biomarker levels were significantly reduced vs placebo. The most frequent adverse events in dupilumab-treated patients were injection-site reaction, conjunctivitis, and nasopharyngitis.Conclusions and RelevanceIn this post hoc analysis of 6 randomized clinical trials, treatment with dupilumab resulted in rapid, sustained improvements in AD signs and symptoms with acceptable safety in patients with erythrodermic AD, similar to those in the trials’ overall patient population.Trial RegistrationClinicalTrials.gov Identifiers: NCT01859988, NCT02277743, NCT02277769, NCT03054428, NCT02260986, NCT02755649

show abstract

Dermoscopy as an auxiliary tool in the differentiation of the main types of erythroderma due to dermatological disorders

Cited by 45 publications

References 7 publications

Dermoscopy in General Dermatology: A Practical Overview

Dermoscopy in General Dermatology: A Practical Overview

Alternative uses of dermoscopy in general dermatology

Efficacy and Safety of Dupilumab in Patients With Erythrodermic Atopic Dermatitis

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