Dermoscopy for “true” amelanotic melanoma: A clinical dermoscopic-pathologic case study

Giorgi, Vincenzo De; Sestini, Serena; Massi, Daniela; Maio, Vincenza; Giannotti, B.

doi:10.1016/j.jaad.2005.04.040

Cited by 39 publications

(47 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These patterns were usually combined with additional (one to two) vascular features. These findings reinforce the impression that MCC should be considered as a dermoscopic differential diagnosis of amelanotic presentations of melanoma including desmoplastic melanoma [10,11,12,13,14,15,16,17,18,19]. …”

Section: Discussionsupporting

confidence: 78%

Dermoscopy of Merkel Cell Carcinoma

et al. 2012

View full text Add to dashboard Cite

Introduction: Merkel cell carcinoma (MCC) is an aggressive cutaneous tumor whose clinical presentation, usually a pink nodule, is not specific. We aimed in this study to determine the dermoscopic criteria encountered in MCC. Methods: From our image database we selected the patients diagnosed with MCC and scored the dermoscopic criteria shown by these tumors. Results: Ten patients coming from three different academic hospitals were studied. Vascular structures were the more relevant dermoscopic features. In 8 out of 10 (80%) patients a polymorphic vascular pattern was seen, composed of milky-red clods/areas in association with one or more additional vascular structures. Conclusion: Although an overlap existed between the dermoscopic features observed in MCC and amelanotic melanoma, the presence of a polymorphous vascular pattern may constitute an additional clinical clue to accurately diagnose this rare tumor.

show abstract

Section: Discussionsupporting

confidence: 78%

Dermoscopy of Merkel Cell Carcinoma

et al. 2012

View full text Add to dashboard Cite

show abstract

“…[4][5][6][7][8] Still, dermoscopic evaluation has been shown to be superior to naked eye examination for the diagnosis of amelanotic or hypomelanotic melanoma. 4 To assess the diagnos-tic significance of dermoscopic features in these lesions, a large series of melanomas as well as nonmelanocytic and benign melanocytic lesions lacking significant pigment was examined.…”

Section: Discussionmentioning

confidence: 99%

Dermoscopic Evaluation of Amelanotic and Hypomelanotic Melanoma

Menzies¹,

Kreusch²,

Byth³

et al. 2008

Arch Dermatol

275

293

View full text Add to dashboard Cite

“…Vascular patterns (linear irregular vessels or the combination of dotted and linear irregular vessels) were the only dermoscopic criteria reliably seen in the ‘truly’ amelanotic melanomas and were felt to be useful in distinguishing amelanotic/hypomelanotic melanoma permitting a correct diagnosis in 4 of 10 cases. The presence of vascular patterns with a peripheral pigment network has been identified as being of diagnostic importance for melanoma [32,33,34,35,36,37,38], and in pure amelanotic melanomas milky red globules and/or areas with irregular linear vessels may be useful [38]. Validation of these dermoscopic criteria in amelanotic melanoma is pending, given the rarity of these lesions and the lack of large-scale prospective studies.…”

Section: Discussionmentioning

confidence: 99%

The Diagnostic Accuracy of in vivo Confocal Scanning Laser Microscopy Compared to Dermoscopy of Benign and Malignant Melanocytic Lesions: A Prospective Study

Langley

Walsh²,

Sutherland³

et al. 2007

Dermatology

112

View full text Add to dashboard Cite

Background: The diagnosis of melanoma at an early, curable stage is an important challenge for clinicians. Confocal scanning laser microscopy (CSLM) is a high-resolution, noninvasive technology that may facilitate improved diagnostic accuracy over clinical examination. The aim of this study was to evaluate the diagnostic accuracy of CSLM compared to dermoscopy in a prospective examination of benign and malignant melanocytic lesions. Methods: 125 patients with suspicious pigmented lesions were prospectively recruited to undergo a clinical, dermoscopic and CSLM examination. A diagnosis was made preoperatively with each technique, and the lesion was then excised and diagnosed using histopathology. Results: 125 patients with 125 lesions were studied comprising 88 melanocytic nevi and 37 melanomas. Dermoscopy had a sensitivity of 89.2%, a specificity of 84.1%, a positive predictive value of 70.2% and a negative predictive value of 94.9%. CSLM was found to have a sensitivity of 97.3%, a specificity of 83.0%, a positive predictive value of 70.6% and a negative predictive value of 98.6%. No melanomas were misidentified when both techniques were used together. Conclusions: CSLM had a relatively higher sensitivity than dermoscopy; however, the specificity was similar with CSLM and dermoscopy. These results suggest that dermoscopy and CSLM are complementary.

show abstract

Dermoscopy for “true” amelanotic melanoma: A clinical dermoscopic-pathologic case study

Cited by 39 publications

References 10 publications

Dermoscopy of Merkel Cell Carcinoma

Dermoscopy of Merkel Cell Carcinoma

Dermoscopic Evaluation of Amelanotic and Hypomelanotic Melanoma

The Diagnostic Accuracy of in vivo Confocal Scanning Laser Microscopy Compared to Dermoscopy of Benign and Malignant Melanocytic Lesions: A Prospective Study

Contact Info

Product

Resources

About