Descriptive Epidemiology of Cerebral Gliomas in Northwest Greece and Study of Potential Predisposing Factors, 2005–2007

Gousias, K.; Μάρκου, Μαρία; Voulgaris, Spyridon; Goussia, A.; Voulgari, Paraskevi V.; Bai, Ma Ci-wang; Polyzoidis, Konstantinos S.; Kyritsis, Athanassios P.; Alamanos, Yannis

doi:10.1159/000222090

Cited by 67 publications

(52 citation statements)

References 62 publications

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“…These differences could be attributed to racial, genetic, and environmental factors, which may influence the development of primary brain tumors [4]. For example, cerebral glioma appears to be more common in the Caucasian population than in Japan, Hispanic-Americans, and African Americans [15,28,29,30,31]. …”

Section: Discussionmentioning

confidence: 99%

Epidemiology of Malignant and Non-Malignant Primary Brain Tumors in Jordan

Tamimi

Abdelaziz

et al. 2015

Neuroepidemiology

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Background: There is lack of knowledge on the epidemiological characteristics of brain tumors in Middle Eastern countries. The objective of this study was to study the epidemiological features of primary brain tumors in Jordan. Methods: We conducted a prospective cohort study incorporating data from 16 hospitals in Jordan during a 1 year period (May 1, 2011-April 30, 2012). All primary brain tumors diagnosed in Jordan during the study period were identified. The following parameters were retrieved from patients' files: age, gender, histological type, and location. The demographic data of the country was obtained from the National Department of Statistics. Results: A total of 313 primary brain tumors were identified during the study period. The incidence of primary brain tumors in Jordan among the general population was 5.01 per 100,000 person-years (5.38 in females and 4.65 in males). The incidence in pediatric, adult, and elderly patients was 2.09, 7.29, and 14.38 per 100,000 person-years, respectively. The most common histological types were meningioma (26.2%), glioblastoma (18.9%), astrocytoma (14.1%), and pituitary adenoma (9.3%). Conclusions: The incidence of primary brain tumors in the Jordanian population is relatively low, in part due to the young age of the general population.

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Section: Discussionmentioning

confidence: 99%

Epidemiology of Malignant and Non-Malignant Primary Brain Tumors in Jordan

Tamimi

Abdelaziz

et al. 2015

Neuroepidemiology

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“…[8][9][10][11][12][13][14][15][16][17] The estimated odds ratios from the largest case-control study including 416 cases were not consistent with an association. 13 Of the other casecontrol studies, most of which included less than 150 cases, two reported an increased risk of glioma associated with increased consumption of wine 8 and increased consumption of beer, liquor and total alcohol.…”

Section: Discussionmentioning

confidence: 99%

“…Those that have, have reported inconsistent results. [8][9][10][11][12][13][14][15][16][17] Some of these studies were small, did not distinguish glioma from meningioma, and were affected by cases' poor recall of alcohol consumption due to cognitive impairment from rapidly progressing tumors and side-effects of treatment. …”

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confidence: 99%

Alcohol consumption and risk of glioblastoma; evidence from the Melbourne collaborative cohort study

Baglietto

Giles

English

et al. 2011

Intl Journal of Cancer

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Despite the brain being highly susceptible to the action of alcohol and, therefore, potentially susceptible to its carcinogenic effects, it is not clear whether alcohol consumption is associated with risk of glioblastoma. We analyzed data from 39,766 participants of the Melbourne Collaborative Cohort Study recruited in 1990-1994 and followed to the end of 2008 for an average of 15 years. Incidence of glioblastoma of the brain was ascertained via linkage to the Victorian and other State cancer registries in Australia. During a structured face-to-face interview at baseline we elicited each participant's history of alcoholic beverage consumption during the current decade at baseline. We used Cox regression models with age as the time metric, adjusted for country of birth, sex, total energy intake, educational attainment and coffee consumption to estimate hazard ratios (HR) and corresponding 95% confidence intervals (CI). A total of 67 glioblastomas was diagnosed in the cohort during follow-up. The HRs associated with each additional 10 grams per day of alcohol intake was 1.16 (95% CI, 1.05 to 1.29; p for linear trend 5 0.007). Compared to lifetime abstainer, the HR for glioblastoma associated with alcohol consumption were 1.07 (0.55 to 2.10) for 1 to 19 g/day, 1.79 (0.81 to 3.95) for 20 to 39 g/day, 3.07 (1.26 to 7.47) for 40 to 59 g/day and 2.54 (0.92 to 7.00) for 60 or more g/day. Alcohol consumption at baseline was associated with the risk of glioblastoma in a dose-response relationship.Glioblastoma is the most common and most aggressive histological subtype of cranial glioma with a 5-year survival of less than 5%.1 The causes of glioblastoma are poorly understood, the only established environmental factor being ionizing radiation. 2,3Using the Melbourne Collaborative Cohort Study (MCCS) 4 we initially investigated the potential associations of well-known risk factors for cancer including body mass index (BMI), smoking, level of education, and alcohol consumption with the risk of glioblastoma. In this article, we present results for alcohol consumption.Alcohol is neurotoxic and several studies, particularly of alcoholics, have described the short and long-term effects of excessive alcohol consumption on brain function and pathology. 5 The mechanisms responsible for these effects are complex and still partly unknown. The effects on the brain of low or moderate alcohol consumption are less clear and more controversial but some studies suggest that low to moderate alcohol consumption might alter brain function and decrease brain health.6 Alcohol is also an established carcinogen and epidemiologic studies have shown that it is associated with increased risk of several types of cancer including breast cancer and cancers of the upper and lower aero-digestive tract.7 Despite the brain clearly being susceptible to the action of alcohol and potentially susceptible to its carcinogenic effects, few epidemiological studies have tested the association between alcohol consumption and risk of glioma. Those that have, have repo...

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“…The average annual age-adjusted IR of GBM is variable, ranging from 0.59 per 100,000 persons to 3.69 per 100,000 persons (11,(13)(14)(15)(16)(17), and is the highest among malignant primary brain tumors (Table 1).…”

Section: Incidence Of Glioblastomamentioning

confidence: 99%

Epidemiology and Outcome of Glioblastoma

2017

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Glioblastoma (GBM) is the most aggressive malignant primary brain tumor. With an incidence rate of 3.19 per 100,000 persons in the United States and a median age of 64 years, it is uncommon in children. The incidence is 1.6 times higher in males compared to females and 2.0 times higher in Caucasians compared to Africans and Afro-Americans, with lower incidence in Asians and American Indians. GBM is commonly located in the supratentorial region (frontal, temporal, parietal, and occipital lobes) and is rarely located in cerebellum. Genetic and environmental factors have been investigated in GBM. Risk factors include prior radiotherapy, decreased susceptibility to allergy, immune factors and immune genes, as well as some single nucleotide polymorphisms detected by genomic analysis. Use of anti-inflammatory medication has been found to be protective against GBM. Survival from GBM is poor; only few patients survive 2.5 years and less than 5% of patients survive 5 years following diagnosis. Survival rates for patients with GBM have shown no notable improvement in population statistics in the last three decades. Molecular epidemiology integrates molecular technology into epidemiological studies and outcomes. The future of the epidemiology of Epidemiology of Glioblastoma 144GBM will depend on multicenter studies generating large clinical data sets of genomic data potentially leading to further understanding of the roles of genes and environment in the development of this devastating disease.

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Descriptive Epidemiology of Cerebral Gliomas in Northwest Greece and Study of Potential Predisposing Factors, 2005–2007

Cited by 67 publications

References 62 publications

Epidemiology of Malignant and Non-Malignant Primary Brain Tumors in Jordan

Epidemiology of Malignant and Non-Malignant Primary Brain Tumors in Jordan

Alcohol consumption and risk of glioblastoma; evidence from the Melbourne collaborative cohort study

Epidemiology and Outcome of Glioblastoma

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