Desempenho funcional de pacientes com fibrose cística e indivíduos saudáveis no teste de caminhada de seis minutos

Pereira, Fabíola Meister; Ribeiro, Maria Ângela Gonçalves de Oliveira; Ribeiro, Antônio Fernando; Toro, Adyléia Aparecida Dalbo Contrera; Hessel, Gabriel; Ribeiro, José Dirceu

doi:10.1590/s1806-37132011000600006

Cited by 21 publications

(27 citation statements)

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“…In contrast, we found no association between TRV and the 6 MWT distance. The limited distances achieved by our patients during the 6 MWT were comparable to those recently reported in children with SCD [40], [41], and in children with different chronic conditions such as juvenile idiopathic arthritis, hemophilia, spina bifida, and mildly to moderately symptomatic cystic fibrosis [42], [43]. Interestingly, Waltz et al showed that a high level of anemia, low fetal hemoglobin expression, and low red blood cell deformability independently predicted poor 6 MWT performance [41].…”

Section: Discussionsupporting

confidence: 85%

Severe Nocturnal and Postexercise Hypoxia in Children and Adolescents with Sickle Cell Disease

et al. 2014

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Hypoxia is a common feature in children with sickle cell disease (SCD) that is inconsistently associated with painful crises and acute chest syndrome. To assess the prevalence and risk factors of hypoxia, we recorded daytime, nocturnal, and postexercise pulse oximetry (SpO2) values in 39 SCD patients with a median age of 10.8 years. Median daytime SpO2 was 97% (range, 89%–100%), and 36% of patients had daytime hypoxia defined as SpO2<96%. Median nocturnal SpO2 was 94.7% (range, 87.7%–99.5%), 50% of patients had nocturnal hypoxia defined as SpO2≤93%, and 11(37%) patients spent more than 10% of their total sleep time with SpO2<90%. Median postexercise SpO2 was 94% (range, 72%–100%) and 44.7% of patients had postexercise hypoxia defined as an SpO2 decrease ≥3% after a 6-minute walk test. Among patients with normal daytime SpO2, 35% had nocturnal and 42% postexercise hypoxia. Compared to 9 patients without daytime, nocturnal, or postexercise hypoxia, 25 patients with hypoxia under at least one of these three conditions had greater anemia severity (P = 0.01), lower HbF levels (P = 0.04), and higher aspartate aminotransferase levels (P = 0.03). Males predominated among patients with postexercise hypoxia (P = 0.004). Hypoxia correlated neither with painful crises nor with acute chest syndrome. Of 32 evaluable patients, 6 (18.8%) had a tricuspid regurgitation velocity ≥2.6 m/s, and this feature was associated with anemia (P = 0.044). Median percentage of the predicted distance covered during a 6-minute walk test was 86% [46–120]; the distance was negatively associated with LDH (P = 0.044) and with a past history of acute chest syndrome (P = 0.009). In conclusion, severe episodes of nocturnal and postexercise hypoxia are common in children with SCD, even those with normal daytime SpO2.

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Section: Discussionsupporting

confidence: 85%

Severe Nocturnal and Postexercise Hypoxia in Children and Adolescents with Sickle Cell Disease

et al. 2014

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“…However, there was no significant correlation between the 6MWT and the gender. Similarly, Pereira et al, 15 who compared functional performance during the 6MWT of 55 patients with cystic fibrosis with 115 healthy individuals, with a mean age of 12.2 ± 4.3 years and 11.3 ± 4.3 years respectively, found that sex has no influence on walk distance of the 6MWT, whose correlations occur only with age, weight and height.…”

Section: Discusionmentioning

confidence: 90%

“…21 At the end of the test and three minutes later, the values of the HR, FR, SpO 2 , PA and modified Borg scale variables were measured, the evaluator again checked the same variables. 15 The mean distance of the 6MWT is 576m for men and 494m for women. 16…”

Section: Methodsmentioning

confidence: 99%

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Evaluation of respiratory muscle strength and functional capacity in patients with cystic fibrosis

et al. 2016

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Objective: To correlate the respiratory muscle strength and functional capacity in patients with CF. Method: Cross-sectional study in adults with cystic fibrosis. Sampling data were cataloged in Microsoft Office Excel 2007 and the variables analyzed by SPSS version 20.0 using the Student t test and the Spearman coefficient. The level of significance adopted was p < 0.05. Results: We assessed 35 patients with cystic fibrosis (44.6 ± 19.0 years), the great majority of patients in FC (n=22) did not present weakness of the inspiratory muscles (MIP-90,7 ± 27.4 cmH2O). It was not found statistically significant differences only between the adult and elderly patients. There was a positive correlation between MIP and MEP and a six-minute walk test (6MWT) in participants with respiratory muscle weakness and in the elderly. There was statistically significant difference between the averages of the distance covered on the 6MWT and the maximal respiratory pressures with the average of what was envisaged for these variables. Conclusion: All groups presented limitation of respiratory strength and functional capacity. The correlations between the respiratory pressures with the 6MWT were low and small in adults and individuals without respiratory muscle weakness; moderate to high in the elderly; small to moderate in women; small and negative in men; and high in patients with respiratory muscle weakness.

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“…The benefits of exercise in patients with CF include improved aerobic conditioning, decreased progression of lung disease, and enhanced bronchial hygiene through an increased ciliary beat frequency, activation of immune cells, reduced susceptibility to viral infections, and increased anti-inflammatory activity. Thus, patients experience a better quality of life [ 1 , 6 - 8 ].…”

Section: Introductionmentioning

confidence: 99%

Ventilatory abnormalities in patients with cystic fibrosis undergoing the submaximal treadmill exercise test

et al. 2015

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BackgroundExercise has been studied as a prognostic marker for patients with cystic fibrosis (CF), as well as a tool for improving their quality of life and analyzing lung disease. In this context, the aim of the present study was to evaluate and compare variables of lung functioning. Our data included: (i) volumetric capnography (VCAP) parameters: expiratory minute volume (VE), volume of exhaled carbon dioxide (VCO2), VE/VCO2, ratio of dead space to tidal volume (VD/VT), and end-tidal carbon dioxide (PetCO2); (ii) spirometry parameters: forced vital capacity (FVC), percent forced expiratory volume in the first second of the FVC (FEV1%), and FEV1/FVC%; and (iii) cardiorespiratory parameters: heart rate (HR), respiratory rate, oxygen saturation (SpO2), and Borg scale rating at rest and during exercise. The subjects comprised children, adolescents, and young adults aged 6–25 years with CF (CF group [CFG]) and without CF (control group [CG]).MethodsThis was a clinical, prospective, controlled study involving 128 male and female patients (64 with CF) of a university hospital. All patients underwent treadmill exercise tests and provided informed consent after study approval by the institutional ethics committee. Linear regression, Kruskal–Wallis test, and Mann–Whitney test were performed to compare the CFG and CG. The α value was set at 0.05.ResultsPatients in the CFG showed significantly different VCAP values and spirometry variables throughout the exercise test. Before, during, and after exercise, several variables were different between the two groups; statistically significant differences were seen in the spirometry parameters, SpO2, HR, VCO2, VE/VCO2, PetCO2, and Borg scale rating. VCAP variables changed at each time point analyzed during the exercise test in both groups.ConclusionVCAP can be used to analyze ventilatory parameters during exercise. All cardiorespiratory, spirometry, and VCAP variables differed between patients in the CFG and CG before, during, and after exercise.Electronic supplementary materialThe online version of this article (doi:10.1186/s12890-015-0056-5) contains supplementary material, which is available to authorized users.

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Desempenho funcional de pacientes com fibrose cística e indivíduos saudáveis no teste de caminhada de seis minutos

Cited by 21 publications

References 22 publications

Severe Nocturnal and Postexercise Hypoxia in Children and Adolescents with Sickle Cell Disease

Severe Nocturnal and Postexercise Hypoxia in Children and Adolescents with Sickle Cell Disease

Evaluation of respiratory muscle strength and functional capacity in patients with cystic fibrosis

Ventilatory abnormalities in patients with cystic fibrosis undergoing the submaximal treadmill exercise test

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