Desensitization for the Prevention of Drug Hypersensitivity
Jeong-Eun Yun,
Jiung Jeong,
Hye-Ryun Kang
Abstract:Drug desensitization is a treatment strategy for patients with hypersensitivity to essential drugs without alternatives. The gradual increase in the drug dosage from low doses to therapeutic levels induces a transient immune tolerance to the culprit drug. Although desensitization has traditionally been recommended for IgE-mediated immediate hypersensitivity, this indication has recently been expanded to include non-IgE-mediated immediate responses, nonimmunological responses, and T-cell mediated delayed hypers… Show more
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