Desensitization to a whole egg by rush oral immunotherapy improves the quality of life of guardians: A multicenter, randomized, parallel-group, delayed-start design study

Itoh-Nagato, Naoka; Inoue, Yuzaburo; Nagao, Mizuho; Fujisawa, Takao; Shimojo, Naoki; Iwata, Tadahisa; Adachi, Yuichi; Arakawa, Koichi; Arima, Takayasu; Fukushima, Keitaro; Hoshioka, Akira; Igarashi, Takashi; Itazawa, Toshiko; Itoh, Komei; Kameda, Makoto; Kando, Naoyuki; Kato, Izumi; Kitabayashi, Taeru; Kobayashi, Takae; Koyama, Harumi; Morita, Yoshinori; Nakano, Taiji; Suzuki, Shinichi; Takaoka, Yuri; Tomiita, Minako; Yagi, Hisako; Yajima, Yuko; Yamaide, Akiko; Yasui, Masayoshi; Yoshihara, Shigemi

doi:10.1016/j.alit.2017.07.007

Cited by 43 publications

(69 citation statements)

References 16 publications

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“…OIT studies have employed a 2-week elimination before OFC, 28,29 F I G U R E 3 Changes in casein-sIgG and sIgG 4 levels between the baseline and after 3 y. A, Casein-sIgG level in the LOIT group and the historical control group.…”

Section: Discussionmentioning

confidence: 99%

Long‐term follow‐up of fixed low‐dose oral immunotherapy for children with severe cow’s milk allergy

Miura

Nagakura

Nishino

et al. 2021

Pediatric Allergy Immunology

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Cow's milk (CM) allergy, one of the major food allergies with a prevalence of 2%-3%, 1,2 accounts for 21% of food-induced anaphylaxis in the UK. 3 In Japan, CM is the second most common cause of food allergy in children. Although about 50%-90% of children with childhood-onset CM allergy acquire tolerance by school age, 4,5 children with severe CM allergy that have high CM-specific immunoglobulin E (sIgE) levels and a history of anaphylaxis often have persistent CM allergy. 4,6

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Section: Discussionmentioning

confidence: 99%

Long‐term follow‐up of fixed low‐dose oral immunotherapy for children with severe cow’s milk allergy

Miura

Nagakura

Nishino

et al. 2021

Pediatric Allergy Immunology

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show abstract

“…Patients (43 patients, 37 males and 6 females, average age 7.3 ± 2.1 years) were confirmed to have hen's egg allergy by oral challenge test at the enrollment and received rush OIT that enabled 38 participants to eat about 1 egg (60 g) and 1 g of egg white powder per day without unbearable adverse effects, such as refractory gastroenteritis and/or severe anaphylaxis (28). These patients kept eating this amount of egg for 12 months.…”

Section: Methodsmentioning

confidence: 99%

Histamine-releasing factor enhances food allergy

Ando

Kashiwakura

Itoh-Nagato

et al. 2017

Journal of Clinical Investigation

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“…143 A Japanese study concluded that rush OIT to egg was able to induce desensitization, but caused frequent adverse events. 144 A Spanish study of 101 children with egg allergy randomized to faster (dose increase of 30% weekly plus 5% daily) or slower (30% weekly) concluded that the faster group was more likely to reach maintenance (96.15% vs 75.80%) and had fewer allergic reactions. 145 The target or maintenance dose of OIT varied greatly in studies and affects the goal outcome of OIT, that is, introduction into the diet vs protection from cross-contamination.…”

Section: Clinic Al Mark Er S and Pro Cedur Al Fac Tor S Of Tre Atmementioning

confidence: 99%

Recent developments and highlights in food allergy

Eiwegger

Hung

Diego

et al. 2019

Allergy

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The achievement of long-lasting, safe treatments for food allergy is dependent on the understanding of the immunological basis of food allergy. Accurate diagnosis is essential for management. In recent years, data from oral food challenges have revealed that routine allergy testing is poor at predicting clinical allergy for tree nuts, almonds in particular. More advanced antigen-based tests including component-resolved diagnostics and epitope reactivity may lead to more accurate diagnosis and selection of therapeutic intervention. Additional diagnostic accuracy may come from cellular tests such as the basophil activation test or mast cell approaches. In the context of clinical trials, cellular tests have revealed specific T-cell and B-cell populations that are more abundant in food-allergic individuals with distinct mechanistic features.Awareness of clinical markers, such as the ability to eat baked forms of milk and egg, continues to inform the understanding of natural tolerance development.Mouse models have allowed for investigation into multiple mechanisms of food allergy including modification of epithelial metabolism, and the induction of regulatory cell subsets and the microbiome. Increasing numbers of children who underwent food immunotherapy enlarged the body of evidence on mechanisms and predictors of treatment success. Experimental immunological markers in conjunction with clinical determinants such as lower age and lower initial specific IgE appear to be of benefit.More research on the optimal dose, preparation, and route of application integrating a high-level safety and efficacy is demanded. Alternatively, biologics blocking TSLP, IL-33, IL-4 and IL-13, or IgE may help to achieve that. K E Y W O R D Sallergy treatment, biologics, food allergy, immune tolerance, immunotherapy | 2357 EIWEGGER Et al.

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Desensitization to a whole egg by rush oral immunotherapy improves the quality of life of guardians: A multicenter, randomized, parallel-group, delayed-start design study

Abstract: rOIT induced desensitization to egg and thus improved the QOL of guardians; however, the participants experienced frequent allergic reactions due to the treatment.

Cited by 43 publications

References 16 publications

Long‐term follow‐up of fixed low‐dose oral immunotherapy for children with severe cow’s milk allergy

Long‐term follow‐up of fixed low‐dose oral immunotherapy for children with severe cow’s milk allergy

Histamine-releasing factor enhances food allergy

Recent developments and highlights in food allergy

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