Design and applications of metal-based molecular receptors and probes for inorganic phosphate

Raju, Mandapati V. Ramakrishnam; Harris, Sarah Miller; Pierre, Valérie C.

doi:10.1039/c9cs00543a

Cited by 74 publications

(48 citation statements)

References 103 publications

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“…Hirashima et al and Honda and Saito suggested that the type of excipients or impurities in products can affect the frequency of precipitate formation during hemodialysis. 10,13) Interestingly, a precipitate in serum was observed only under conditions of higher serum concentrations of NFM (1 mg/mL) and citrate (2 mM) (Fig. 5).…”

Section: Discussionmentioning

confidence: 91%

“…In some pharmaceutical products that contain NFM, citric acid or succinic acid are sometimes included to control the pH of the prepared solution. 10) Such additives may become anionic electrolytes and exchange with the mesilate of NFM. Hirashima et al and Honda and Saito suggested that the type of excipients or impurities in products can affect the frequency of precipitate formation during hemodialysis.…”

Section: Discussionmentioning

confidence: 99%

“…Although Arishima et al reported on precipitate formation in the circuit of blood flow, 9) Hirashima et al detected precipitates in the infusion tube. In hemodialysis, 10) the infusion rate of NFM (2-5 mL/h) is much slower than blood flow (6 L/h). Such differences in rates of infusion and blood flow may cause backflow from the region of faster flow (blood flow) to the region of slower flow (NFM infusion), resulting the accumulation of un-cleared precipitates in the infusion tube.…”

Section: Discussionmentioning

confidence: 99%

“…[5][6][7][8] In contrast to such a variety of uses, the formation of a precipitate during the infusion of NFM into blood, especially during hemodialysis could lead to the interruption of hemodialysis. 9,10) The pharmaceutical formulation of NFM is a lyophilized powder with some added excipients (e.g., mannitol or pH controller). It is generally administered in a 5% glucose solution and not physiological saline, since mesilate of NFM can be exchanged by some anionic salts such as chloride, resulting in the formation of insoluble salts.…”

Section: Introductionmentioning

confidence: 99%

“…9,10,13) Hirashima et al and Honda and Saito proposed that the type of excipients being used or impurities in the products could account for this difference. 10,13) Citric acid or succinic acid are sometimes included in some pharmaceutical products that contain NFM, to control the pH of prepared solution. Such additives may function as anionic electrolytes that could exchange with the mesilate of NFM.…”

Section: Introductionmentioning

confidence: 99%

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Possible Role of Electrolytes on the Formation of Precipitates during the Infusion of Nafamostat Mesilate in Hemodialysis

Yamasaki

Nishi

Tsukigawa

et al. 2021

Biological & Pharmaceutical Bulletin

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Nafamostat mesilate (NFM) is used as an anticoagulant during hemodialysis in patients who have had complications due to hemorrhages. The formation of precipitates, which could lead to the interruption of hemodialysis has been reported when NFM is infused into blood during hemodialysis. We report herein on an examination of possible factors that could cause this. The effects of electrolytes such as phosphates, citrates or succinates on the formation of precipitates were examined by mixing NFM with aqueous solutions or plasma that contained these electrolytes. The formation of precipitates was observed in all electrolyte solutions when higher concentrations of NFM were mixed at around physiological pH. In the case of plasma, precipitates were observed when solutions containing higher concentrations of NFM were mixed with plasma that contained phosphate and citrate. In addition, the formation of precipitates under dynamic conditions where NFM was infused into flowing electrolyte solutions was also evaluated. The data suggested that such precipitates might be formed and disrupt the blood flow and/or an NFM infusion when NFM is infused into blood flowing in the hemodialysis circuit. The findings presented herein suggest the serum levels of anionic electrolytes (e.g., phosphate), the type of excipients present in pharmaceutical products (e.g., succinic acid or citric acid), the concentration of NFM used for the infusion or the rates of NFM infusion and blood flow are all factors that could affect precipitate formation during NFM infusions for hemodialysis.

show abstract

Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Possible Role of Electrolytes on the Formation of Precipitates during the Infusion of Nafamostat Mesilate in Hemodialysis

Yamasaki

Nishi

Tsukigawa

et al. 2021

Biological & Pharmaceutical Bulletin

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Recognition‐based Sensors for Cellular Imaging

Bowyer¹,

Zhu²,

New³

2022

Molecular Fluorescent Sensors for Cellular Studies

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Synthesis of Two New Dinuclear Lanthanide Clusters and Visual Bifunctional Sensing Devices Based on the Eu Cluster

Jiang

Zheng

Liu

et al. 2021

Advanced Optical Materials

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The development of visual and multifunctional sensors, and further the fabrication of portable sensing devices is of great importance. Herein, two dinuclear lanthanide clusters are designed, and their accurate molecules are determined to be [Ln2(DFBA)6(dmp)2(H2O)2] (Ln3+ = Eu3+ (1‐Eu) or Tb3+ (1‐Tb), HDFBA = 3,4‐difluorobenzoic acid, dmp = 4,7‐dimethyl‐1,10‐phenanthroline), by single‐crystal X‐ray diffraction. Interestingly, 1‐Eu shows rapid detection of ferrous ions (Fe2+) and acetylacetone (acac), with the limit of detection (LOD) as low as 5.6 and 1.0 ppb, respectively. LOD of 5.6 ppb for Fe2+ is far lower than the standard of World Health Organization (0.3 ppm, SDWA) and Chinese rural water quality standards (0.5 ppm, GB25467‐2010) for drinking water. As far as it is known, 1‐Eu is the most sensitive chemosensor for the detection of acac; the sensing can be discriminated by the naked eyes under 365 nm UV light. Furthermore, portable sensing devices of agarose gel, test paper, and sprayed films on plastic tube, glass, coin, test paper, stone, leaf, carbon rod, and iron sheet surfaces, based on 1‐Eu solution, are fabricated by facile methods, with visual and quick detection of Fe2+ in water under various conditions, and show excellent recyclable sensing performance for acac vapor.

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Design and applications of metal-based molecular receptors and probes for inorganic phosphate

Abstract: We discuss and review the strategies of metal-based receptors targeting phosphate.

Cited by 74 publications

References 103 publications

Possible Role of Electrolytes on the Formation of Precipitates during the Infusion of Nafamostat Mesilate in Hemodialysis

Possible Role of Electrolytes on the Formation of Precipitates during the Infusion of Nafamostat Mesilate in Hemodialysis

Recognition‐based Sensors for Cellular Imaging

Synthesis of Two New Dinuclear Lanthanide Clusters and Visual Bifunctional Sensing Devices Based on the Eu Cluster

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