Design and development of a new ultrasonic doppler technique for estimation of the aggregation of red blood cells

Karabetsos, Efthymios; Papaodysseus, C.; Koutsouris, D.

doi:10.1016/s0263-2241(98)00053-0

Cited by 25 publications

(6 citation statements)

References 22 publications

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“…In the present work additional structural characteristics regarding the flow of aggregates of specific sizes in the channel were analysed. The aggregate size distributions in the entire channel are exponential in nature, and agree qualitatively very well with those observed in previous studies [30].…”

Section: Discussionsupporting

confidence: 90%

Red blood cell aggregate flux in a bifurcating microchannel

Kaliviotis

Pasias

Sherwood

et al. 2017

Medical Engineering & Physics

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Red blood cell aggregation plays a key role in microcirculatory flows, however, little is known about the transport characteristics of red blood cell aggregates in branching geometries. This work reports on the fluxes of red blood cell aggregates of various sizes in a T-shaped microchannel, aiming to clarify the effects of different flow conditions in the outlet branches of the channel. Image analysis techniques, were utilised, and moderately aggregating human red blood cell suspensions were tested in symmetric (~50-50%) and asymmetric flow splits through the two outlet (daughter) branches. The results revealed that the flux decreases with aggregate size in the inlet (parent) and daughter branches, mainly due to the fact that the number of larger structures is significantly smaller than that of smaller structures. However, when the flux in the daughter branches is examined relative to the aggregate size flux in the parent branch an increase with aggregate size is observed for a range of asymmetric flow splits. This increase is attributed to size distribution and local concentration changes in the daughter branches. The results show that the flow of larger aggregates is not suppressed downstream of a bifurcation, and that blood flow is maintained, for physiological levels of red blood cell aggregation.

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Section: Discussionsupporting

confidence: 90%

Red blood cell aggregate flux in a bifurcating microchannel

Kaliviotis

Pasias

Sherwood

et al. 2017

Medical Engineering & Physics

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“…Irrespective of the intensity of shearing,

never reaches

, but asymptotes to zero for extreme values of the shear rate. In other words, blood never becomes fully unstructured., which agrees with the experimental data by Karabetsos et al [ 88 ]. The relaxation time follows almost the same pattern as the structure parameter (Equation (13)), exhibiting a smoother variation.…”

Section: Steady and Transient Rheological Predictionssupporting

confidence: 93%

Advanced Constitutive Modeling of the Thixotropic Elasto-Visco-Plastic Behavior of Blood: Description of the Model and Rheological Predictions

et al. 2020

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This work focuses on the advanced modeling of the thixotropic nature of blood, coupled with an elasto-visco-plastic formulation by invoking a consistent and validated model for TEVP materials. The proposed model has been verified for the adequate description of the rheological behavior of suspensions, introducing a scalar variable that describes dynamically the level of internal microstructure of rouleaux at any instance, capturing accurately the aggregation and disaggregation mechanisms of the RBCs. Also, a non-linear fitting is adopted for the definition of the model’s parameters on limited available experimental data of steady and transient rheometric flows of blood samples. We present the predictability of the new model in various steady and transient rheometric flows, including startup shear, rectangular shear steps, shear cessation, triangular shear steps and LAOS tests. Our model provides predictions for the elasto-thixotropic mechanism in startup shear flows, demonstrating a non-monotonic relationship of the thixotropic index on the shear-rate. The intermittent shear step test reveals the dynamics of the structural reconstruction, which in turn is associated with the aggregation process. Moreover, our model offers robust predictions for less examined tests such as uniaxial elongation, in which normal stress was found to have considerable contribution. Apart from the integrated modeling of blood rheological complexity, our implementation is adequate for multi-dimensional simulations due to its tensorial formalism accomplished with a single time scale for the thixotropic effects, resulting in a low computational cost compared to other TEVP models.

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“…Because of their suitability for analyzing non-stationary signals, they have become a powerful alternative to Fourier methods in many applications, where such signals abound (Akay, 1997;Burrus, Gopinath, & Guo, 1998;Coifman & Wickerhauser, 1992;Devasahayam, 2000;Karabetsos, Papaodysseus, & Koutsouris, 1998;Liang & Nartimo, 1998;Quiroga, 1998;Quiroga, Roso, & Basar, 1999).…”

Section: Wavelet Packet Decompositionmentioning

confidence: 99%

An expert system based on least square support vector machines for diagnosis of the valvular heart disease

Hanbay

2009

Expert Systems with Applications

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Design and development of a new ultrasonic doppler technique for estimation of the aggregation of red blood cells

Cited by 25 publications

References 22 publications

Red blood cell aggregate flux in a bifurcating microchannel

Red blood cell aggregate flux in a bifurcating microchannel

Advanced Constitutive Modeling of the Thixotropic Elasto-Visco-Plastic Behavior of Blood: Description of the Model and Rheological Predictions

An expert system based on least square support vector machines for diagnosis of the valvular heart disease

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