Design and development of spirulina polysaccharide-loaded nanoemulsions with improved the antitumor effects of paclitaxel

Du, Manling; Yang, Zhenjiang; Lü, Wenping; Wang, Bingyue; Wang, Qi; Жен, Чен; Chen, Lianyu; Han, Shuyu; Cai, Tiange; Cai, Yu

doi:10.1080/02652048.2020.1767224

Cited by 27 publications

(13 citation statements)

References 39 publications

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“…For instance, nanoemulsions loaded with spirulina and paclitaxel showed an improved anti-tumor effect by regulating immunity through TLR4/NF-kB signaling pathways [ 84 ]. Nanoemulsion consisting of rapamycin, bevacizumab, and temozolomide is known to treat advanced melanoma [ 85 ]. Nanoemulsions are different from liposomes and certainly have enhanced characteristics than others, such as optical clarity, stability, and biodegradability [ 86 ].…”

Section: Nanoparticles In Cancer Therapymentioning

confidence: 99%

Nanoparticles for Cancer Therapy: Current Progress and Challenges

Gavas¹,

2021

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Cancer is one of the leading causes of death and morbidity with a complex pathophysiology. Traditional cancer therapies include chemotherapy, radiation therapy, targeted therapy, and immunotherapy. However, limitations such as lack of specificity, cytotoxicity, and multi-drug resistance pose a substantial challenge for favorable cancer treatment. The advent of nanotechnology has revolutionized the arena of cancer diagnosis and treatment. Nanoparticles (1–100 nm) can be used to treat cancer due to their specific advantages such as biocompatibility, reduced toxicity, more excellent stability, enhanced permeability and retention effect, and precise targeting. Nanoparticles are classified into several main categories. The nanoparticle drug delivery system is particular and utilizes tumor and tumor environment characteristics. Nanoparticles not only solve the limitations of conventional cancer treatment but also overcome multidrug resistance. Additionally, as new multidrug resistance mechanisms are unraveled and studied, nanoparticles are being investigated more vigorously. Various therapeutic implications of nanoformulations have created brand new perspectives for cancer treatment. However, most of the research is limited to in vivo and in vitro studies, and the number of approved nanodrugs has not much amplified over the years. This review discusses numerous types of nanoparticles, targeting mechanisms, and approved nanotherapeutics for oncological implications in cancer treatment. Further, we also summarize the current perspective, advantages, and challenges in clinical translation.

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Section: Nanoparticles In Cancer Therapymentioning

confidence: 99%

Nanoparticles for Cancer Therapy: Current Progress and Challenges

Gavas¹,

2021

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“…Co-delivery by nanoemulsions is one of the methods to enhance bioavailability and drug efficacy. The test results of a NE drug carrier system loaded with spirulina polysaccharides and PTX showed that it could improve the anti-tumor effect of PTX by regulating immunity through Toll-like receptor 4/nuclear factor kappa B (TLR4/NF-κB) signaling pathways [ 105 ]. A nanoemulsion system consisting of temozolomide, rapamycin, and bevacizumab was established to treat advanced melanoma.…”

Section: Nanomaterials Used For Cancer Treatmentmentioning

confidence: 99%

Nanomaterials for cancer therapy: current progress and perspectives

et al. 2021

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Cancer is a disease with complex pathological process. Current chemotherapy faces problems such as lack of specificity, cytotoxicity, induction of multi-drug resistance and stem-like cells growth. Nanomaterials are materials in the nanorange 1–100 nm which possess unique optical, magnetic, and electrical properties. Nanomaterials used in cancer therapy can be classified into several main categories. Targeting cancer cells, tumor microenvironment, and immune system, these nanomaterials have been modified for a wide range of cancer therapies to overcome toxicity and lack of specificity, enhance drug capacity as well as bioavailability. Although the number of studies has been increasing, the number of approved nano-drugs has not increased much over the years. To better improve clinical translation, further research is needed for targeted drug delivery by nano-carriers to reduce toxicity, enhance permeability and retention effects, and minimize the shielding effect of protein corona. This review summarizes novel nanomaterials fabricated in research and clinical use, discusses current limitations and obstacles that hinder the translation from research to clinical use, and provides suggestions for more efficient adoption of nanomaterials in cancer therapy.

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“…Co-delivery using NEs can be performed to improve the effects and bioavailability of drugs. A previous study showed that an NE carrier containing paclitaxel (PTX) and Spirulina polysaccharides displayed improved anticancer effects by regulating the TLR4/NF-κB signaling pathways ( 76 ). An NE system composed of rapamycin and bevacizumab was developed.…”

Section: Nanoemulsionsmentioning

confidence: 99%

Current Progress in Cancer Treatment Using Nanomaterials

et al. 2022

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The pathological processes of cancer are complex. Current methods used for chemotherapy have various limitations, such as cytotoxicity, multi-drug resistance, stem-like cells growth, and lack of specificity. Several types of nanomaterials are used for cancer treatment. Nanomaterials 1–100 nm in size have special optical, magnetic, and electrical characteristics. Nanomaterials have been fabricated for cancer treatments to overcome cytotoxicity and low specificity, and improve drug capacity and bioavailability. Despite the increasing number of related studies, few nanodrugs have been approved for clinical use. To improve translation of these materials, studies of targeted drug delivery using nanocarriers are needed. Cytotoxicity, enhanced permeability and retention effects, and the protective role of the protein corona remain to be addressed. This mini-review summarizes new nanomaterials manufactured in studies and in clinical use, analyses current barriers preventing their translation to clinical use, and describes the effective application of nanomaterials in cancer treatment.

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Design and development of spirulina polysaccharide-loaded nanoemulsions with improved the antitumor effects of paclitaxel

Cited by 27 publications

References 39 publications

Nanoparticles for Cancer Therapy: Current Progress and Challenges

Nanoparticles for Cancer Therapy: Current Progress and Challenges

Nanomaterials for cancer therapy: current progress and perspectives

Current Progress in Cancer Treatment Using Nanomaterials

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