Design and evaluation a kind of functional biomaterial for bone tissue engineering: Selenium/mesoporous bioactive glass nanospheres

Hu, Mengqi; Fang, Jie; Zhang, Ying; Wang, Xiang; Zhong, Wenxing; Zhou, Zhufa

doi:10.1016/j.jcis.2020.06.122

Cited by 49 publications

(39 citation statements)

References 70 publications

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“…Meng et al prepared multifunctional Se/MBG nanospheres with different Se contents. [77] The results showed that tetravalent Se, as a network-forming cation significantly improves the bioactivity of MBG nanospheres. Moreover, Se/MBG nanospheres had selective cytotoxic effects on cancer cells (MG63) and normal cells (MC3T3-E1): i) trace concentrations increase the vitality of normal cells, but have no significant effect on tumor cells; ii) moderate concentrations are toxic to tumor cells, but maintain non-toxicity in normal cells; iii) elevated concentration has obvious toxic effects on both normal cells and tumor cells, but more sensitive to tumor cells.…”

Section: Bgs With Rare-earth Ionsmentioning

confidence: 95%

Research Progress of Bioactive Glass and Its Application in Orthopedics

Huang

Yu²,

et al. 2021

Adv Materials Inter

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effectively promote the expression of vascular endothelial growth factor (VEGF) in fibroblasts, and promote angiogenesis in vivo and in vitro [4] ; iii) ions and degradation products released from BGs can activate and up-regulate gene expression in bone progenitor cells, resulting in rapid bone regeneration and a higher rate of bone formation compared with other inorganic ceramics such as hydroxyapatite (HA), ttitanium dioxide, aluminium oxide. [5] In this paper, we review a series of breakthroughs and progresses in the application of BG, and discuss the future prospects of BG in bone regeneration, with the hope to provide a reference for further research on BGs.

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Section: Bgs With Rare-earth Ionsmentioning

confidence: 95%

Research Progress of Bioactive Glass and Its Application in Orthopedics

Huang

Yu²,

et al. 2021

Adv Materials Inter

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“…11 , we must indicate that the solid lines signify well-established properties on which there is a broad consensus on the part of the scientific community, whereas the dashed lines correspond to biological effects more recently proposed or with a minor consensus degree. For instance, Li is considered anti-inflammatory and proposed as osteogenic [ 72 ], B is considered angiogenic and proposed as osteogenic [ 73 ], Se, is recently proposed as antiangiogenic and cancer preventive [ 74 ], Ta, which is gaining much recent notoriety as a hemostatic agent [ 75 ], and so on. Likewise, the presence of several lanthanide therapeutic elements investigated to be added to MBGs, such as Ce [ 76 ], Sm [ 77 ], Eu [ 78 ], or Tb [ 79 ], must be highlighted.…”

Section: Expanding Mesoporous Glass Properties By Adding Inorganic Ionsmentioning

confidence: 99%

Mesoporous bioactive glasses for regenerative medicine

Vallet‐Regí

Salinas

2021

Materials Today Bio

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Stem cells are the central element of regenerative medicine (RM). However, in many clinical applications, the use of scaffolds fabricated with biomaterials is required. In this sense, mesoporous bioactive glasses (MBGs) are going to play an important role in bone regeneration because of their striking textural properties, quick bioactive response, and biocompatibility. As other bioactive glasses, MBGs are mainly formed by silicon, calcium, and phosphorus oxides whose ions play an important role in cell proliferation as well as in homeostasis and bone remodeling process. A common improvement of bioactive glasses for RM is by adding small amounts of oxides of elements that confer them additional biological capacities, including osteogenic, angiogenic, antibacterial, anti-inflammatory, hemostatic, or anticancer properties. Moreover, MBGs are versatile in terms of the different ways in which they can be processed, such as scaffolds, fibers, coatings, or nanoparticles. MBGs are unique because their textural properties are so high that they still exhibit outstanding bioactive responses even after adding extra inorganic ions or being processed as scaffolds or nanoparticles. Moreover, they can be further improved by loading with biomolecules, drugs, and stem cells. This article reviews the state of the art and future perspectives of MBGs in the field of RM of hard tissues.

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“…Besides, compared to 45S5 BG, Se-doped 45S5 BG accelerated the mineralization process in vitro but presented lower APL activity [ 375 ]. Hu et al [ 376 ] evaluated the cytotoxic effect of selenium doping in mesoporous bioactive glass nanospheres (60 SiO 2 –(36– x ) CaO–4 P 2 O 5 – x SeO 2 with x = 0, 1, 3, and 5 in mol%). MG 63 osteosarcoma and MC3T3-E1 preosteoblast cells were incubated for 48 h with Se-MBG supernatants.…”

Section: Bioactive Glasses Doped With Other Elementsmentioning

confidence: 99%

“…All the Se-MBG-containing nanospheres were significantly toxic for MG 63 cells. However, the Se 4+ ion concentrations (0, 1, and 3 in mol%) in MBG nanospheres were nontoxic to MC3T3-E1 cells, while 5 mol% Se (5Se-MBG)-containing nanospheres were significantly toxic for MC3T3-E1 cells at concentrations higher than 20 µg/ml [ 376 ]. 3Se-MBG and 5Se-MBG nanospheres showed a significant apoptosis effect on MG 63 cells compared to the control.…”

Section: Bioactive Glasses Doped With Other Elementsmentioning

confidence: 99%

“…3Se-MBG and 5Se-MBG nanospheres showed a significant apoptosis effect on MG 63 cells compared to the control. The Se-free MBG and other Se-MBG nanospheres showed no obvious ability to induce apoptosis [ 376 ]. Alternatively, DOX was successfully loaded into Se-MBG nanospheres to improve the viability of MG 63 cells resulting in slightly higher viability than the positive control (free DOX).…”

Section: Bioactive Glasses Doped With Other Elementsmentioning

confidence: 99%

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Bioactive glasses incorporating less-common ions to improve biological and physical properties

Pantulap

Arango‐Ospina

Boccaccını

2021

J Mater Sci: Mater Med

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Bioactive glasses (BGs) have been a focus of research for over five decades for several biomedical applications. Although their use in bone substitution and bone tissue regeneration has gained important attention, recent developments have also seen the expansion of BG applications to the field of soft tissue engineering. Hard and soft tissue repair therapies can benefit from the biological activity of metallic ions released from BGs. These metallic ions are incorporated in the BG network not only for their biological therapeutic effects but also in many cases for influencing the structure and processability of the glass and to impart extra functional properties. The “classical” elements in silicate BG compositions are silicon (Si), phosphorous (P), calcium (Ca), sodium (Na), and potassium (K). In addition, other well-recognized biologically active ions have been incorporated in BGs to provide osteogenic, angiogenic, anti-inflammatory, and antibacterial effects such as zinc (Zn), magnesium (Mg), silver (Ag), strontium (Sr), gallium (Ga), fluorine (F), iron (Fe), cobalt (Co), boron (B), lithium (Li), titanium (Ti), and copper (Cu). More recently, rare earth and other elements considered less common or, some of them, even “exotic” for biomedical applications, have found room as doping elements in BGs to enhance their biological and physical properties. For example, barium (Ba), bismuth (Bi), chlorine (Cl), chromium (Cr), dysprosium (Dy), europium (Eu), gadolinium (Gd), ytterbium (Yb), thulium (Tm), germanium (Ge), gold (Au), holmium (Ho), iodine (I), lanthanum (La), manganese (Mn), molybdenum (Mo), nickel (Ni), niobium (Nb), nitrogen (N), palladium (Pd), rubidium (Rb), samarium (Sm), selenium (Se), tantalum (Ta), tellurium (Te), terbium (Tb), erbium (Er), tin (Sn), tungsten (W), vanadium (V), yttrium (Y) as well as zirconium (Zr) have been included in BGs. These ions have been found to be particularly interesting for enhancing the biological performance of doped BGs in novel compositions for tissue repair (both hard and soft tissue) and for providing, in some cases, extra functionalities to the BG, for example fluorescence, luminescence, radiation shielding, anti-inflammatory, and antibacterial properties. This review summarizes the influence of incorporating such less-common elements in BGs with focus on tissue engineering applications, usually exploiting the bioactivity of the BG in combination with other functional properties imparted by the presence of the added elements.

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Design and evaluation a kind of functional biomaterial for bone tissue engineering: Selenium/mesoporous bioactive glass nanospheres

Cited by 49 publications

References 70 publications

Research Progress of Bioactive Glass and Its Application in Orthopedics

Research Progress of Bioactive Glass and Its Application in Orthopedics

Mesoporous bioactive glasses for regenerative medicine

Bioactive glasses incorporating less-common ions to improve biological and physical properties

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