Design and evaluation of solid self-emulsifying drug delivery system of rosuvastatin calcium

Abstract

Background:The work has been undertaken with an objective to prepare a self-emulsifying drug delivery system (SEDDS) of rosuvastatin calcium (ROS) with the least amount of surfactant which could enhance its solubility and oral bioavailability. Materials and Methods: Spectrophotometric method was used to estimate the solubility of the drug in various oils, surfactant and co-surfactant. The phase behavior and most efficient self-emulsifying region were identified by constructing pseudo ternary phase diagram. The solid-SEDDS (S-SEDDS) was prepared using an adsorbent consequently the prepared S-SEDDS were filled up in hard gelatin capsule which were evaluated for various physicochemical parameters. Results: The composition of optimized formulation consisted of 10 mg of ROS, capmul MCM (oil), cremophor ELP (surfactant) and propylene glycol (co-surfactant). The optimized formulation showed negative zeta potential (−22.11 mv), optimal particle size (10.59 nm) and demonstrated excellent self-emulsifying ability with a maximum solubilizing capability. The S-SEDDS formulations were prepared from the optimized liquid SEDDS, which revealed maximum release rate (97.7%) among all the prepared S-SEDDS formulation and marketed formulation. Conclusion: It was concluded that S-SEDDS prepared from liquid SEDDS can be a promising novel approach to enhance the solubility and drug release of ROS, which in turn also develops a stable formulation, least drugs leakage and precipitation than the liquid SEDDS.

Self-nanoemulsifying Drug Delivery System (Snedds) for Topical Delivery of Mangosteen Peels (Garcinia Mangostana L.,): Formulation Design and In vitro Studies

“…The clarity of emulsion can be observed by transparency, which can be measured in form of % transmittance (%T). 25 In the equation, transmittance reveals that the interaction between the VCO and Tween 80 provide coefficient with a negative value. It shows that such interaction lowers transmittance value SNEDDS.…”

“…Samples selected from the mangosteen peels (5,10,15,20,25.30, 50, 75, 100, 125,150 mg) were added to 5 mL SNEDDS optimal formulation. This referred to making a solid dispersion method technique.…”

Self-emulsifying drug delivery systems and the application in drugs and cosmetics

“…Đánh giá nhũ tương thu được bằng quan sát cảm quan và bằng kính hiển vi. Vùng hình thành vi nhũ tương trên giản đồ pha là vùng dung dịch trong suốt đồng nhất hoặc trong mờ [26][27][28]. Cách này thường được áp dụng trong xây dựng công thức SMEDDS.…”

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“…Two milliliters of each of the selected vehicle (oil/ surfactant/cosurfactant) were added to each capped vial containing an excess of drug. [9] After sealing, the mixture was shaken well and vortexed for 2 min for proper mixing of drug with the vehicle until suspension was formed. Formed suspensions were then shaken using orbital shaking incubator at 25°C for 48 h. Supernatant was collected and centrifuged at 3000 rpm for 15 min to sediment undissolved drug present if any.…”