Biomechanics is the examination of the structure and function of biological systems by means of the methods of mechanics. Finite element analysis is a computer-based numerical analysis method that can be used to calculate the response of a model to a set of well-defined boundary conditions. Although typical analysis methods, FE analysis can be used to analyze structures of complicated geometry and inhomogeneous material properties. The finite element method is an ideal method for analyzing live tissues such as femur bone this is since it has complex geometric shapes and inhomogeneous material properties. The objective of an FE analysis is to find the distribution of an unknown within a body. In this research, a simplified model of the femur with some of the inner structures (trabeculae, Haversian canals, marrow) was designed. After designing, a simplified model, FE analysis, and optimization were done. Obtained results showed that the max stress is 5.2717e8 Pa. It reached 4.5687e8 Pa after optimization of the model.