A typical example of discrete event systems (DESs) is a reconfigurable manufacturing system (RMS) whose can be changed and become more complicated during its operation. Thus, an effective tool needs to be developed to create both high-and low-level DES implementation. The ladder diagram (LD) is a common programming method for controlling DESs. Petri nets (PNs) represent the most important graphical and mathematical tool that can be used to provide an integrated solution for the design, modeling, analysis, control, and implementation of DESs. Various types of PN-based LDs are developed for DESs, which have high structural complexity of the LDs. Therefore, an approach that can facilitate the elimination of the LDs' structural complexity needs to be developed. The main objective of this paper is to develop a two-step approach for LDs implementation for RMSs with dynamic changes. First, a colored resource-oriented Petri net (CROPN)-based algorithm is proposed for a rapid and valid configurations of an RMS. Second, a ladder diagram colored resource-oriented Petri net (LDCROPN) is developed to convert the CROPN into an LD. The developed approach is evaluated using examples in the literature. Moreover, the results demonstrate the effectiveness of the developed approach for LD implementation under RMS specification changes.