This article presents a quad-band multiple-input-multiple-output (MIMO) antenna for the Internet of Things (IoT) applications. The proposed antenna consists of four quarter-wavelength asymmetrical meandered radiators, microstrip feed lines, and modified ground planes. The antenna elements are arranged in a chiral pattern to improve isolation between them, with two radiators and two ground planes placed on the front side of the substrate and the other two on the back side. The MIMO antenna has an operating bandwidth (S11 ≤ −10 dB) of 1.76–1.84 GHz, 2.37–2.56 GHz, 3.23–3.68 GHz, and 5.34–5.84 GHz, covering GSM, WLAN, WiMAX, and 5G frequency bands. The isolation between the radiating elements is greater than 18 dB in the operating bands. The peak gain of the antenna is 3.6 dBi, and the envelope correlation coefficient (ECC) is less than 0.04. Furthermore, the proposed antenna is validated for IoT-based smart home (SH) applications. The prototype MIMO antenna is integrated with a commercially available ZigBee device, and the measured values are found to be consistent with the expected results. The proposed MIMO antenna could be a good candidate for IoT systems/modules due to its low profile, compact size, lightweight, and easy integration with wireless communication devices.