Design and in vitro evaluation of formulations with pH and transit time controlled sigmoidal release profile for colon-specific delivery

Asghar, Laila Fatima Ali; Azeemuddin, Md.; Jain, Varun; Chandran, Sajeev

doi:10.1080/10717540902989936

Cited by 8 publications

(1 citation statement)

References 38 publications

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“…The graphical representation of drug content of all formulation batches of naproxen matrix tablets at room temperature and accelerated temperature is shown in Figure 10. [37]…”

Section: Resultsmentioning

confidence: 99%

Formulation and in vitro evaluation of Eudragit S-100 coated naproxen matrix tablets for colon-targeted drug delivery system

Rohit

Chawla

Sharma

et al. 2013

J Adv Pharm Technol Res

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The purpose of the present investigation was to prepare matrix tablets of naproxen using a hydrophobic polymer, i.e., Eudragit RLPO, RSPO, and combination of both, by wet granulation method. The tablets were further coated with different concentrations of Eudragit S-100, a pH-sensitive polymer, by dip immerse method. In vitro drug release studies of tablets were carried out in different dissolution media, i.e., 0.1 N HCl (pH 1.2), phosphate buffers pH 6.8 and 7.4, with or without rat cecal content. The swelling studies of the optimized formulation were carried out. The physicochemical parameters of all the formulations were found to be in compliance with the pharmacopoeial standards. The effect of dissolution medium on the surface of matrix tablet was determined by using Scanning Electron Microscopy technique. The stability studies of all formulations were performed as per ICH guidelines. The results demonstrated that the tablets coated with Eudragit S-100 (2% w/v) showed a sustained release of 94.67% for 24 h, but drug release increased to about 98.60% for 24 h in the presence of rat cecal content while the uncoated tablets released the drug within 5 h. With regard to release kinetics, the data were best fitted with the Higuchi model with non-Fickian drug release kinetics mechanism. The stability studies of tablets showed less degradation during accelerated and room temperature storage conditions for 6 months. The enteric-coated Eudragit S-100 coated matrix tablets of naproxen showed promising site-specific drug delivery in the colon region.

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“…The graphical representation of drug content of all formulation batches of naproxen matrix tablets at room temperature and accelerated temperature is shown in Figure 10. [37]…”

Section: Resultsmentioning

confidence: 99%