Design and in vitro evaluation of adhesive matrix for transdermal delivery of propranolol

Polymeric Hydrogels: Characterization and Biomedical Applications

“…The diffusion of the drug through the hydrogels may be affected by the property (viz., pH sensitivity, light sensitivity, pressure sensitivity) of the hydrogel, depending on the chemistry of the hydrogels and has been used successfully to design delivery systems which may release drug at a suitable environment. The drug transport mechanisms can be determined by fitting the early time release data to the following empirical relationship [40,41]: where M t is amount of drug released at a given time t, M ∞ amount of drug released at infinite time and k and n are constants (characteristic of the drug-polymer system). The diffusional exponent, n, is dependent on the geometry of the device, as well as the physical mechanism of release.…”

Design of Meloxicam and Lornoxicam Transdermal Patches: Preparation, Physical Characterization, ex Vivo and in Vivo Studies

“…The presence of PG and increase in its concentration in the film accelarated drug diffusion rate probably by formation of hydrophilic micropores in the film structure and by increasing drug solubility. 11,19) Permeability coefficients calculated are presented in Table 4. Drug diffusion through matrix was also thought to be influenced by delayed crystallization behaviour of drugs due to existence of PG in films and PG-polymer interaction indicated in DSC experiment.…”

Transdermal Drug Delivery Systems: A Mini Review.

“…The drug reservoir is prepared by directly dispersing the drug in an adhesive polymer which is then spread by solvent casting or heating molding onto a flat sheet of drug-impermeable backing to form a thin drug reservoir layer. In order to formulate an adhesive diffusion-controlled drug delivery system, a layer of nonmedicated, rate-controlling adhesive polymer with constant thickness should be spread onto it (Guyot and Fawaz 2000).…”