Design and investigation of nanoemulsified carrier based on amphiphile-modified hyaluronic acid

Kong, Ming; Chen, Xiguang; Park, Hyunjin

doi:10.1016/j.carbpol.2010.08.001

Cited by 43 publications

(26 citation statements)

References 29 publications

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“…Different batches of amphiphilic HA-GMS were synthesized by a previous method (Kong, Chen & Park, 2011), labeled as H6.5, H23 and L6 (capitals denote MW property of HA and the latter numbers are substituting degree of HA-GMS). Nanoemulsions were prepared through oil/water/surfactant (O/W/S) emulsifying system and solvent evaporation as previous paper .…”

Section: Preparation Of Ha-gms Nanoemulsionsmentioning

confidence: 99%

Investigations on skin permeation of hyaluronic acid based nanoemulsion as transdermal carrier

Kong

Chen

Kweon

et al. 2011

Carbohydrate Polymers

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169

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Section: Preparation Of Ha-gms Nanoemulsionsmentioning

confidence: 99%

Investigations on skin permeation of hyaluronic acid based nanoemulsion as transdermal carrier

Kong

Chen

Kweon

et al. 2011

Carbohydrate Polymers

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169

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“…To evaluate the effects of amplitudes and time on particle size and zeta potential during ultrasonication, CS-g-PLA solution (1 mg/ml, 20 ml) was ultrasonicated at specified amplitudes (30,40, and 50) and durations (4, 6, 10, and 16 min). For simplicity, the ultrasonication conditions were denoted as AxDy, where x represented the amplitude and y represented the duration.…”

Section: Pcs Nps Prepared By Diafiltration Combined With Ultrasonicatmentioning

confidence: 99%

“…The size distribution and zeta potential of PCS NPs was determined using dynamic light scattering [30] (DLS, ZEN3600, Malvern Instruments Ltd., Worcestershire, UK).…”

Section: Characterization Of Pcs Npsmentioning

confidence: 99%

Preparation of biocompatible chitosan grafted poly(lactic acid) nanoparticles

Kong

Cheng

et al. 2012

International Journal of Biological Macromolecules

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“…The contents were stirred for 15 minutes to ensure nanoemulsion formation, which was monitored by checking the optical clarity and physical properties of the system. To prepare the novel BSA NEDDS, a blank formula and different concentrations of BSA power and aqueous solution, being 5,10,15,20,25,30,35,40,45,50,55, and 60 mg/mL, were used following the same protocol and method to the pseudoternary phase diagram construction, with the exception of water being replaced by BSA as the aqueous phase.…”

Section: Formulation Of the Bsa Neddsmentioning

confidence: 99%

“…16 NEDDS possesses high kinetic and long-term thermodynamic stability and transparency. Therefore, it has been widely used to improve the stability of drugs such as ramipril, 17 celecoxib, 18 hyaluronic acid, 19,20 β-cypermethrin, 21 β-carotene, 22,23 β-cyclodextrin 24 and Bacillus anthracis protective antigen. 25 NEDDS possesses a good storage capacity and thermodynamic stability for drug delivery.…”

Section: Introductionmentioning

confidence: 99%

Development and characterization of a novel nanoemulsion drug-delivery system for potential application in oral delivery of protein drugs

Sun¹,

Liu²,

Liu³

et al. 2012

IJN

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Background:The stability of protein drugs remains one of the key hurdles to their success in the market. The aim of the present study was to design a novel nanoemulsion drug-delivery system (NEDDS) that would encapsulate a standard-model protein drug -bovine serum albumin (BSA) -to improve drug stability. Methods: The BSA NEDDS was prepared using a phase-inversion method and pseudoternary phase diagrams. The following characteristics were studied: morphology, size, zeta potential, drug loading, and encapsulation efficiency. We also investigated the stability of the BSA NEDDS, bioactivity of BSA encapsulated within the NEDDS, the integrity of the primary, secondary, and tertiary structures, and specificity. Results: The BSA NEDDS consisted of Cremophor EL-35, propylene glycol, isopropyl myristate, and normal saline. The average particle diameter of the BSA NEDDS was about 21.8 nm, and the system showed a high encapsulation efficiency (.90%) and an adequate drugloading capacity (45 mg/mL). The thermodynamic stability of the system was investigated at different temperatures and pH levels and in room-temperature conditions for 180 days. BSA NEDDS showed good structural integrity and specificity for the primary, secondary, and tertiary structures, and good bioactivity of the loaded BSA. Conclusions: BSA NEDDS showed the properties of a good nanoemulsion-delivery system. NEDDS can greatly enhance the stability of the protein drug BSA while maintaining high levels of drug bioactivity, good specificity, and integrity of the primary, secondary, and tertiary protein structures. These findings indicate that the nanoemulsion is a potential formulation for oral administration of protein drugs. Keywords: nanoemulsion, drug-delivery system, protein drug, oral administration, stability IntroductionMany protein targets and protein drugs have recently been discovered, with approximately a dozen therapeutic protein drugs receiving regulatory approval each year around the world.1,2 Over 125 protein drugs are already in the US market, and the value of advanced drug-delivery systems in this market had reached $121 billion by 2010.3 Although many varieties of protein drugs have been designed for therapeutic purposes, several challenges remain, including enzymatic susceptibility, stability during storage period, and efficacy after administration. 4 Thus, protein stability is one of the major hurdles for a drug's successful entry into the market. 5 At present, many of the marketed protein drugs are mainly designed for injective delivery. Because of the thermal instability of protein drugs, they need to be stored and transported at cold temperatures in order to ensure long shelf life. 5,6Dovepress submit your manuscript | www.dovepress.com To overcome the crucial problem of protein instability, stabilizers such as nonionic surfactants, cyclodextrin derivatives, poloxamers, glycerol, ethylene glycol, glucose, sucrose, and trehalose have been used. 7 However, the effects of these stabilizers vary among different proteins. With a view to en...

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Design and investigation of nanoemulsified carrier based on amphiphile-modified hyaluronic acid

Cited by 43 publications

References 29 publications

Investigations on skin permeation of hyaluronic acid based nanoemulsion as transdermal carrier

Investigations on skin permeation of hyaluronic acid based nanoemulsion as transdermal carrier

Preparation of biocompatible chitosan grafted poly(lactic acid) nanoparticles

Development and characterization of a novel nanoemulsion drug-delivery system for potential application in oral delivery of protein drugs

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