Design and optimization of polymerization parameters of carboxymethyl chitosan and sodium 2-acrylamido-2-methylpropane sulfonate hydrogels as wound dressing materials

Kalaithong, Wichaya; Molloy, Robert; Nalampang, Kanarat; Somsunan, Runglawan

doi:10.1016/j.eurpolymj.2020.110186

Cited by 25 publications

(14 citation statements)

References 26 publications

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“…As depicted in Figure 2D , the FTIR spectra of CMCTS-Tk and CMCTS were clearly displayed. CMCTS showed strong peaks at 1,597 cm− 1 and 1,407 cm− 1 , which corresponded to the carboxy group and carboxymethyl group, respectively ( Kalaithong et al, 2021 ). Besides, a wideband at 3,412 cm− 1 meant stretching vibrations of O–H and N–H bonds, while 2,922 cm− 1 for C–H bonds.…”

Section: Resultsmentioning

confidence: 99%

ROS-Eliminating Carboxymethyl Chitosan Hydrogel to Enhance Burn Wound-Healing Efficacy

et al. 2021

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Overexpression of reactive oxygen species (ROS) can lead to chronic inflammation, which limits skin wound healing. Therefore, it is of great significance to develop materials that can locally control the adverse reactions caused by excessive ROS. In this research, an ROS-sensitive hydrogel with strong free radical scavenging ability was prepared by introducing the thione (Tk) group into carboxymethyl chitosan (CMCTS) hydrogel. CMCTS hydrogel was cross-linked by NH2-Tk-NH2 agent and loaded curcumin (Cur), which possessed favorable nontoxicity, water absorption, mechanical property, biodegradability, drug release behavior, the M2 phenotype, and inflammatory factor regulating the capacity of macrophages. It is worth noting that Cur@CMCTS-Tk hydrogel can significantly inhibit oxidative damage of human fibroblasts in the H2O2-induced microenvironment and protect their viability by reducing the production of intracellular ROS. In vivo, ROS-removing hydrogel effectively accelerated the process of wound healing and possessed good regenerative properties, including hair follicle formation, promotion of new blood vessel formation, and highly orderly arrangement of collagen fibers in the full-thickness skin burn defect rat model. Hence, we expect that the Cur@CMCTS-Tk hydrogel could be used for wound treatment and tissue regeneration due to the ability to scavenge excess ROS.

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Section: Resultsmentioning

confidence: 99%

ROS-Eliminating Carboxymethyl Chitosan Hydrogel to Enhance Burn Wound-Healing Efficacy

et al. 2021

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“…AMPS has been incorporated into various hydrogel wound dressings and injectable hydrogels due to these properties. 21,22 For example, injectable hydrogels containing sulfonate from AMPS have been fabricated using thiol-based copolymers, which were combined with a 4-arm acrylamide-terminated poly(ethylene glycol) through a thiol–ene click reaction. 23 In this work we use acid-containing comonomers to enable the modification step.…”

Section: Introductionmentioning

confidence: 99%

Water-soluble macromers based on 2-acrylamido-2-methyl-1-propanesulfonic acid sodium salt (Na-AMPS) for rapid in situ hydrogel film formation

Daengmankhong,

Ross,

Pinthong

et al. 2024

Polym. Chem.

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“…A wide variety of monomers (including multifunctional acrylate and methacrylate monomers) have been found to undergo rapid photopolymerization under UV light, with the right amount of photoinitiator [ 1 , 2 , 3 ]. However, there are still many problems in the above monomer systems, such as the fact that it is unstable in oxygen, has uneven crosslinking, large internal stress in polymerization, is easy to cause volume shrinkage, and so on [ 4 , 5 , 6 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Study on Fire Behavior, Thermal Stability and Degradation Kinetics of Thiol-Ene with Poly(aminopropyl/phenyl)silsesquioxane

Wang

2022

Polymers

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In this article, the flame retardant poly(aminopropyl/phenyl)silsesquioxane (PA) was incorporated into thiol-ene (TE), to obtain a flame-retardant thiol-ene (FRTE) composite. The cone calorimeter (CONE) measurement results showed that, compared with neat TE, the peak of heat release rate (PHRR) and total heat release (THR) of FRTE have decreased by almost 23.7% and 14.5%, respectively. Thermogravimetric analysis (TGA) results further confirmed that the flame retardant PA could induce the initial thermal degradation of TE, and increased the amounts of residual char. Moreover, the activation energies of FRTE were calculated through the Kissinger and Flynn–Wall–Ozawa methods. Compared with the neat TE, the activation energies of FRTE were raised by the addition of PA. It indicated that the flame retardant PA promoted cross-linking reactions of TE, to form a compact char layer and retarded further the thermal degradation of the polymer matrix.

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Design and optimization of polymerization parameters of carboxymethyl chitosan and sodium 2-acrylamido-2-methylpropane sulfonate hydrogels as wound dressing materials

Cited by 25 publications

References 26 publications

ROS-Eliminating Carboxymethyl Chitosan Hydrogel to Enhance Burn Wound-Healing Efficacy

ROS-Eliminating Carboxymethyl Chitosan Hydrogel to Enhance Burn Wound-Healing Efficacy

Water-soluble macromers based on 2-acrylamido-2-methyl-1-propanesulfonic acid sodium salt (Na-AMPS) for rapid in situ hydrogel film formation

Study on Fire Behavior, Thermal Stability and Degradation Kinetics of Thiol-Ene with Poly(aminopropyl/phenyl)silsesquioxane

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