Design and process development of a photonic crystal polymer biosensor for point-of-care diagnostics

Abstract

In this work, we report advances in the fabrication and anticipated performance of a polymer biosensor photonic chip developed in the European Union project P3SENS (FP7-ICT4-248304). Due to the low cost requirements of point-ofcare applications, the photonic chip is fabricated from nanocomposite polymeric materials, using highly scalable nanoimprint-lithography (NIL). A suitable microfluidic structure transporting the analyte solutions to the sensor area is also fabricated in polymer and adequately bonded to the photonic chip.We first discuss the design and the simulated performance of a high-Q resonant cavity photonic crystal sensor made of a high refractive index polyimide core waveguide on a low index polymer cladding. We then report the advances in doped and undoped polymer thin film processing and characterization for fabricating the photonic sensor chip. Finally the development of the microfluidic chip is presented in details, including the characterisation of the fluidic behaviour, the technological and material aspects of the 3D polymer structuring and the stable adhesion strategies for bonding the fluidic and the photonic chips, with regards to the constraints imposed by the bioreceptors supposedly already present on the sensors.

Investigation of thin polymer layers for biosensor applications

“…The relatively high refractive index of polyimides (n = 1.6-1.7), good preparative characteristics (the layer thickness can be controlled in a wide range by spin coating technique) and low preparative and material costs were promising properties for waveguide application in the P3SENS biosensor project [4]. To reach a sufficient refractive index difference, the PI layer was combined with TEOS (tetraethyl orthosilicate) making a hybrid material system [5,6].…”