Design and simulation of a novel bio nano actuator by prefoldin

Ghaffari, Ali; Shokuhfar, Ali; Ghasemi, Reza Hasanzadeh

doi:10.1109/nano.2010.5697837

Cited by 9 publications

(8 citation statements)

References 16 publications

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“…1,5,7 This unique structure is an excellent choice for designing nanotechnology protein templates. With further research, [69][70][71][72] it was discovered that PFDN has the ability to act as a nano-component in bio-nano-robots, and was gradually designed as a prefoldin nano-actuator (PNA) to act as a drug delivery tool and carrier. 4,69,73,74 The six tentacles of the PNA make it very flexible.…”

Section: Prefoldin and Nanotechnology Prefoldin Can Be Used As A Nanomentioning

confidence: 99%

“…With further research, [69][70][71][72] it was discovered that PFDN has the ability to act as a nano-component in bio-nano-robots, and was gradually designed as a prefoldin nano-actuator (PNA) to act as a drug delivery tool and carrier. 4,69,73,74 The six tentacles of the PNA make it very flexible. When the temperature and pH of the environmental medium are changed, the overall structure and space size of the PNA are significantly affected, and the combination and release of nano-cargo are controlled.…”

Section: Prefoldin and Nanotechnology Prefoldin Can Be Used As A Nanomentioning

confidence: 99%

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<p>The Role of Prefoldin and Its Subunits in Tumors and Their Application Prospects in Nanomedicine</p>

Mo¹,

Zhao²,

Tian³

et al. 2020

CMAR

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Prefoldin (PFDN) is a hexameric chaperone complex that is widely found in eukaryotes and archaea and consists of six different subunits (PFDN1-6). Its main function is to transfer actin and tubulin monomers to the eukaryotic cell cytoplasmic chaperone protein (c-CPN) specific binding during the assembly of the cytoskeleton, to stabilize the newly synthesized peptides so that they can be folded correctly. The current study found that each subunit of PFDN has different functions, which are closely related to the occurrence, development and prognosis of tumors. However, the best characteristics of each subunit have not been fully affirmed. The connection between research and tumors can change the understanding of PFDN and further extend its potential prognostic role and structural function to cancer research and clinical practice. This article mainly reviews the role of canonical PFDN and its subunits in tumors and other diseases, and discusses the potential prospects of the unique structure and function of PFDN in nanomedicine.

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Section: Prefoldin and Nanotechnology Prefoldin Can Be Used As A Nanomentioning

confidence: 99%

Section: Prefoldin and Nanotechnology Prefoldin Can Be Used As A Nanomentioning

confidence: 99%

<p>The Role of Prefoldin and Its Subunits in Tumors and Their Application Prospects in Nanomedicine</p>

Mo¹,

Zhao²,

Tian³

et al. 2020

CMAR

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show abstract

“…The mutant PNA for creating attractive force between PNA and nano cargo at neutral pH and repulsive force at pH 3. and engineering studies. This interesting properties cause, Archaeal Prefoldin is used to create a novel nano actuator that can be used for nanoscale manipulation [18][19][20][21].…”

Section: Prefoldin Nano Actuator (Pna)mentioning

confidence: 99%

Capturing and releasing a nano cargo by Prefoldin nano actuator

Ghaffari

Shokuhfar

Ghasemi

2012

Sensors and Actuators B: Chemical

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“…Unlike eukarya Prefoldin, archaeal Prefoldin is nonspecific. This interesting properties cause, we use archaeal Prefoldin to create a novel nano actuator that can be used for nanoscale manipulation [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Cavity Control of Prefoldin Nano Actuator (PNA) by Temperature and pH

2012

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A molecular dynamics study to investigate the cavity control of Prefoldin based bio nano actuator is presented in this paper. Prefoldin is a molecular chaperone with a jellyfish-like structure containing six long coiled-coil tentacles and a large central cavity. We took the temperature and pH of the medium into account, and analyzed the conformational flexibility of the Prefoldin nano actuator in details. Results show that the prefoldin is a very flexible protein, the conformational state of which appears to depend on the temperature and pH values of the medium. In fact, combining these two control parameters, a suitable environment is provided to capture nano cargoes with specific dimensions. These properties of Prefoldin actuator can be used for drug delivery in the body.

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Design and simulation of a novel bio nano actuator by prefoldin

Cited by 9 publications

References 16 publications

<p>The Role of Prefoldin and Its Subunits in Tumors and Their Application Prospects in Nanomedicine</p>

<p>The Role of Prefoldin and Its Subunits in Tumors and Their Application Prospects in Nanomedicine</p>

Capturing and releasing a nano cargo by Prefoldin nano actuator

Cavity Control of Prefoldin Nano Actuator (PNA) by Temperature and pH

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