Design and synthesis of heterocyclic Compounds from 1,4-diacetylbenzene with Expected Antimicrobial Activity

Abstract

I N this present work, synthesized a novel derivatives of bis-chalcones via condensation of 1,4-diacetylbenzene with different aldehydes in basic media. The reaction of chalcone derivatives 3a,b with thioglycolic acid gave compounds 4a,b. That was reacted with ethyl cyanoacetate in presence of ammonium acetate to give the corresponding cyanopyridine derivatives 5a,b. Furthermore, bis-chalcone 3a,b was cyclization to pyrazole analogs by using 2,4-dinitrophenylhydrazine to give compounds 7a,b in good yields. All products were characterized by IR spectrum, 1 HNMR, 13 CNMR, and elemental analysis. The new compounds have been screened as anti-bacterial activity

Synthesis biological studies of some new heterocyclic compound derived from 2-chloro-3-formyl quinoline and 4-(benzyl sulfonyl) acetophenone

“…The reaction of phenyl hydrazine with chalcones (4,5) afforded compounds (12,13) (scheme-4-) . The IR spectra of these compounds (12,13) showed absorption at (1595 cm -1 and 1591 cm -1 ) for C=N group respectively . H 1 NMR spectra of these compounds showed a single signal at δ 5.31 and δ 5.31 for hydrogen in the pyrazoline ring .…”

“…Based on their in vitro antibacterial activities, screening of the synthesized compounds is done by measuring the inhibition zone in terms of millimetre via the paper disc-agar diffusion technique. The newly synthesized compounds were screened for their antibacterial activities against two representative Grampositive organisms (staphylococcus aureus and staphylococcus epidermidis), and two Gramnegative ( Escherichia coli and Proteus vulgaris) by discdiffusion method [12] ciprofloxacin was used as standard for comparison of antibacterial activities. Antibacterial tests were carried out by the agar diffusion technique [30,31].…”

“…The quinoline skeleton is often used to design of many synthetic compounds [3]. Quinoline derivatives posses useful biological activities such as anti malarial, anti-inflammatory, antibacterial, anticancer, anti-microbial, anthelmintic, anti-fungal besides wide range of pharmacological activities [4][5][6][7][8][9][10][11][12][13][14]. Chloroquinoline compound has been used as prophylactics to prevent the development of malaria [15].…”

“…Chalcones and their derivatives are also medically important. Many chalcones compounds are important class of natural products and as a precursor for synthesis of various heterocyclic compounds like imidazole, pyrazoles, pyrazoline, azetidine, triazole, thiazole and oxadiazole [16][17][18][19] have been reported to posses anti-malaria, anti-inflammatory and antibacterial activity [20,21] . Recently interest in the sulfur-heterocycles compounds have significantly increased since a wide range of biological activities [22] .…”

An efficient colorimetric inspection of ammonia using silver nanoparticles synthesized by 3‐(1‐(2‐(2,4‐dinitrophenyl)hydrazono)ethyl)‐1H‐indole as chemo‐sensors in water environment

“…There is an increase attention towards developing color investigations; it has a feature that can be see easily changes in the presence of targeted guests. Synthetic receptors for anions are usually based on cyclic ammonium/guanidium [1,2] and imidazoleum, [3,4] amides, [5] sulfonamides, [6] carbamates, [7] urea/thiourea, [8][9][10][11] functional calixarenes, [12] aromatics such as pyrrol, carbazole and indole, [13,14] and especially phenylhydrazone [15] that is a type of neutral receptor and has a simple effect synthetic method. Herein, we synthesized 3-(1-(2-(2,4-dinitrophenyl)hydrazono)ethyl)-1H-indole by used simple method for the selective sensing of ammonia.It is recognized in modern literature that current detectors are split into two classes [16] : (1) physical, that is, sensitive to variations in device physical parameters such as pressure, temperature, and so on; (2) chemical, which respond to variations in the system's qualitative and quantitative assembly.…”