2007
DOI: 10.1016/j.bmc.2007.01.010
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Design and synthesis of pyridine–pyrazolopyridine-based inhibitors of protein kinase B/Akt

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Cited by 64 publications
(35 citation statements)
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“…Indazole is a frequently found motif in drug substances with important biological activities, such as antimicrobial (Patel et al, 1999) and anti-inflammatory activities (Lin et al, 2008), and anticancer effects (Zhu et al, 2007). As a continuation of our studies of indazole derivatives (Mohamed Abdelahi et al, 2017a,b,c), we report the synthesis and structure of the title compound (Fig.…”
Section: Structure Descriptionmentioning
confidence: 81%
“…Indazole is a frequently found motif in drug substances with important biological activities, such as antimicrobial (Patel et al, 1999) and anti-inflammatory activities (Lin et al, 2008), and anticancer effects (Zhu et al, 2007). As a continuation of our studies of indazole derivatives (Mohamed Abdelahi et al, 2017a,b,c), we report the synthesis and structure of the title compound (Fig.…”
Section: Structure Descriptionmentioning
confidence: 81%
“…Indazole is a frequently found motif in drug substances with important biological activities such as antimicrobial (Li et al, 2003), anti-inflammatory (Lin et al, 2008) and anticancer effects (Zhu et al, 2007). The crystal structure study of the title compound constitutes a continuation of our previous work on indazole derivatives (Mohamed Abdelahi et al, 2017;El Brahmi et al, 2012).…”
Section: Structure Descriptionmentioning
confidence: 84%
“…Pyrazoline derivatives have been reported to exhibit a wide spectrum of biological effects including anticancer activity [6][7][8][9][10][11][12][13][14][15][16] . Some compounds bearing pyrazole moiety exert their therapeutic action by inhibiting different types of enzymes that play important roles in cell division [16][17][18] . Manna et al synthesized 1-acetyl-3,5-diaryl-4,5-dihydro-(1H)-pyrazole derivatives and investigated their anticancer activity and affinity binding to P-glycoprotein.…”
Section: Introductionmentioning
confidence: 99%