Design, characterization, and clinical evaluation of argan oil nanostructured lipid carriers to improve skin hydration

Tichota, Deise Michele; Silva, Ana Catarina; Lobo, José Manuel Sousa; Amaral, Maria Helena

doi:10.2147/ijn.s64008

Cited by 30 publications

(18 citation statements)

References 42 publications

(48 reference statements)

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“…Tichota et al formulated argan oil NLC-based hydrogel manifesting a synergistic effect on skin hydration (NLC occlusion plus argan oil hydration). 88 Skin hydration can be measured using a corneometer. The instrument works on the mechanism of measuring capacitance or conductance of a dielectric medium.…”

Section: Skin Hydration and Elasticitymentioning

confidence: 99%

“…41 Skin microrelief is used to evaluate skin-hydration efficacy of cosmetics, and could be assessed by measuring the parameters of roughness, scaling, smoothing, and wrinkling. 88 The moisturisation effect of a product leads to the increase in skin hydration, which contributes to wrinkle smoothing and enhancing the penetration of bioactives into specific skin layers. 82 Any alteration in the hydration level of the skin are measured in arbitrary units.…”

Section: Skin Hydration and Elasticitymentioning

confidence: 99%

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Nanostructured Lipid Carriers: A Groundbreaking Approach for Transdermal Drug Delivery

Chauhan¹,

Yasir

Verma³

et al. 2020

Adv Pharm Bull

293

145

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Nanostructured lipid carriers (NLCs) are novel pharmaceutical formulations which are composed of physiological and biocompatible lipids, surfactants and co-surfactants. Over time, as a second generation lipid nanocarrier NLC has emerged as an alternative to first generation nanoparticles. This review article highlights the structure, composition, various formulation methodologies, and characterization of NLCs which are prerequisites in formulating a stable drug delivery system. NLCs hold an eminent potential in pharmaceuticals and cosmetics market because of extensive beneficial effects like skin hydration, occlusion, enhanced bioavailability, and skin targeting. This article aims to evoke an interest in the current state of art NLC by discussing their promising assistance in topical drug delivery system. The key attributes of NLC that make them a promising drug delivery system are ease of preparation, biocompatibility, the feasibility of scale up, non-toxicity, improved drug loading, and stability.

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Section: Skin Hydration and Elasticitymentioning

confidence: 99%

Section: Skin Hydration and Elasticitymentioning

confidence: 99%

Nanostructured Lipid Carriers: A Groundbreaking Approach for Transdermal Drug Delivery

Chauhan¹,

Yasir

Verma³

et al. 2020

Adv Pharm Bull

293

145

View full text Add to dashboard Cite

show abstract

“…After 14 days of application by rice bran oil nanoemulsions, skin moisture increased by 38% in normal control volunteers and by 30% in patients with atopic dermatitis or psoriasis. Tichota et al 67 used argan oil as liquid lipid to prepare nanostructured lipid carriers and further prepared nanostructured lipid carriers-based hydrogel formulation. The formulation has high stability, firmness and adhesion, and can extend the contact time for topical application.…”

Section: Application and Efficacy Evaluation Of Active Cosmetic Ingredient Nanocarriersmentioning

confidence: 99%

Current Advances of Nanocarrier Technology-Based Active Cosmetic Ingredients for Beauty Applications

Zhou¹,

Luo²,

Chen³

et al. 2021

CCID

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Nanocarrier technology has been effectively applied to the development of drug delivery systems to overcome the limitations of traditional preparation. Its application has been extended to various pharmaceutical fields from injection preparation to oral preparation and external preparation, and now it has appeared in the field of cosmetics for beauty applications. The widespread influence of nanocarrier in the cosmetics industry is due to the fact that nanocarrier can effectively promote the percutaneous penetration and significantly increase skin retention of active components in functional cosmetics. Meanwhile, nanocarrier can effectively improve the water dispersion of insoluble active cosmetic ingredients, enhance the stability of efficacy components and achieve the codelivery of diverse cosmetics active ingredients. In this review, we summarized the current progress of nanocarrier technology in the functional cosmetics, including the types and the routes of dermal/ transdermal drug delivery nanocarriers used in the functional cosmetics, the mechanism of nanocarriers promoting the percutaneous penetration of active cosmetic ingredients, the application and efficacy evaluation of different active cosmetic ingredients in nanocarriers and discussing the potential risks to human. This will provide a useful reference for the further development of nanocarriers in the field of functional cosmetics.

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“…This causes the contact time with the skin is short so that the absorption of the active ingredients also decreases and the acceptability is less. 16 The addition of the base will increase the viscosity and contact time on the skin. It will increase skin hydration so that the active ingredients penetrate more easily into the skin.…”

Section: Introductionmentioning

confidence: 99%

The activity of candlenut oil in the nanostructured lipid carrier system on hair growth in rats

Erawati

Rosita

Rachmania

2023

J. Public Health Afr.

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Background: Candlenut oil (Aleurites moluccana L. Willd), which is also called Aleurites moluccana Seed (AMS) oil, is empirically effective as a hair growth agent, it is an unstable substance. Nanostructured Lipid Carrier (NLC) is a delivery system that is proven to increase the effectiveness and stability of the material, and the usage of solid lipid combination: beeswax-oleum cacao can produce good NLC characteristics. Objective: To determine the effectiveness of NLC_AMS oil with different combination of beeswax-oleum cacao (100:0; 50:50; 25:75; and 0:100) as a hair growth agent, using rats as subjects. Methods: NLC-AMS oil was made using 20% of total lipid with 5% AMS oil as liquid lipid and 15% solid lipid; combinations of beeswax-oleum cacao were of different ratios (100:0; 50:50; 25:75; and 0:100). NLC was made by High Shear Homogenization (HPH) method. Hair growth activity test carried out on male white rats using the research methods of Yoon (2010). Results: The addition of oleum cacao as a solid lipid did not affect the pH, but increased the consistency and decreased the particle size of NLC- AMS oil. There was a relationship between the characteristic of NLC and the hair growth activity test: the small particle size and low viscosity had greater hair growth activity. Conclusion: The usage of solid lipid combination: beeswax-oleum cacao can produce better NLC characteristics and had higher hair growth activity than the formulas that used single lipid.

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Design, characterization, and clinical evaluation of argan oil nanostructured lipid carriers to improve skin hydration

Cited by 30 publications

References 42 publications

Nanostructured Lipid Carriers: A Groundbreaking Approach for Transdermal Drug Delivery

Nanostructured Lipid Carriers: A Groundbreaking Approach for Transdermal Drug Delivery

Current Advances of Nanocarrier Technology-Based Active Cosmetic Ingredients for Beauty Applications

The activity of candlenut oil in the nanostructured lipid carrier system on hair growth in rats

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