Design, Characterization and Clinical Evaluation of Curcumin Dental Film for the Treatment of Periodontitis

Samal, Himansu Bhusan; Patra, Chinam Niranjan; Boyeena, Lavanya; Sreenivas, S. A.; Das, Itishree Jogamaya

doi:10.2174/2210303110999201123203946

Cited by 3 publications

(2 citation statements)

References 28 publications

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“…Curcumin improves the performance of the immune system, increases the conservation of the cardiovascular and nervous systems. Also, turmeric extraction prevents the growth of the different strains of pathogenic bacteria and fungi in the mouth and prevents the formation of microbial plaque on the teeth (Corrêa et al, 2017; Nagpal & Sood, 2013; Samal, 2017; Sambhav, Rohit, Ankit Raj, & Garima, 2014; Shah, 2017; Singhla, Tevatia, Chaudhry, Vaish, & Dodwad, 2017; Vaughn et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

“…Turmeric is a member of the ginger family and it is extracted from the rhizomes of the Curcuma longa Linn plant. Turmeric is a yellow flavored spice that can grow approximately up to a height of 1 meter, has spear‐shaped leaves, and its orange pulp grows in the rhizomes of the plan (Izui et al, 2016; Kunnumakkara et al, 2017; Samal, 2017; Shah, 2017; Zou, Helson, Maitra, Stern, & McNeil, 2013).…”

Section: Introductionmentioning

confidence: 99%

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Oral nano‐curcumin on gingival inflammation in patients with gingivitis and mild periodontitis

Malekzadeh

Kia

Mashaei

et al. 2020

Clinical & Exp Dental Res

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Gingivitis can trigger gingival diseases such as periodontitis. Since the complete removal of microbial plaques by mechanical procedures is not conceivable in some conditions and also chemical mouthwashes have a lot of side effects, finding a new treatment strategy would be useful. In the present study, for the first time, the effects of oral nano‐curcumin on gingival inflammation in patients with gingivitis and mild periodontitis were assessed. Forty eight patients with gingivitis and mild periodontitis participated in this clinical trial. In one group the patients were treated with Sina curcumin capsules 80 mg and the other group received a placebo. Clinical parameters, including modified gingival index, papillary bleeding index, and plaque index were determined on days 0, 7, 14, and 28. There were no significant differences in age, sex, papillary bleeding index (PBI), and modified gingival index (MGI) between the two groups at baseline. There was a dropout of two patients (both from the placebo group). The MGI and PBI have a significantly decreasing trend in both case and control groups and the decreases were severe in the case group. The differences between PBI and MGI in the two groups were significant at 14 and 28 days. The plaque index did not significantly change in either group over the study period. The trend of changes in plaque index was not different between the two groups of the study. In the current study, no side effect was found in the patients. Oral nano‐curcumin has positive effects on the decrease of inflammation and gingival bleeding in patients with gingivitis and mild periodontitis. Nano‐curcumin capsules have a systemic target site with more bioavailability than topical forms.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Oral nano‐curcumin on gingival inflammation in patients with gingivitis and mild periodontitis

Malekzadeh

Kia

Mashaei

et al. 2020

Clinical & Exp Dental Res

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Periodontal Film: A Potential Treatment Strategy for Periodontitis

Dastidar¹,

Ash²,

Saha³

et al. 2022

DDL

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Periodontitis is a serious gum infection associated with inflammation of the periodontium around the teeth. Based on the etiology and pathogenesis, periodontitis has several conventional treatment strategies. Treatment with antibiotics and antimicrobials is the most common therapy. However, development of drug resistance and the manifestation of side effects make conventional strategies ineffective. In the last decades, local drug delivery in the periodontal pocket has gained significant attention as a novel strategy. Sustained release of drug at the target site (periodontal pocket) for a prolonged period is the main advantage over conventional therapy. Bioadhesive periodontal films are mostly used. They are thin films made up of unique mixtures of bioadhesive polymers, binders, plasticizers, and drug release modifiers. They can be loaded with antibiotics, metal nanoparticles, metal oxide nanoparticles, or a combination of them. The dried film is cut into a suitable size and inserted into the periodontal pocket for direct delivery of therapeutic agents. Thus, a smaller dose is required and systemic side effects are avoided. In this manuscript, the pathophysiology of periodontitis, the role of biofilm formation, development of periodontal film loaded with antibiotics and nanoparticles have been reviewed and the future aspects have been discussed.

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Impact of the Current Scenario and Future Perspectives for the Management of Oral Diseases: Remarkable Contribution of Herbs in Dentistry

Ahuja

Singh

2022

AIA

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Background: Herbs used in dentistry contain antimicrobial, antiseptic, anti-bacterial, anti-fungal, and antiviral properties that help in reducing irritation, infections, and pain in the oral cavity. The resistance to antibiotics and overcoming their untoward side effects promoted the usage of herbals in dentistry. In addition, due to the affordability issues of allopathic medicines in rural areas, the dependency of poor people on herbal medicines has gained significant popularity in the Indian subcontinent. Objective: Oral disorders would be a significant health setback for humankind due to their severity if they remained untreated. This review promotes the efforts made to overcome the side effects of allopathic medicines and provide cost-effective herbal treatment for oral care. Oral disorders cause various infections like tooth decay, dental caries, gingivitis, fungal, viral, bacterial infections, plaque formation, pemphigus vulgaris, pyorrhoea, mouth ulcers, and oral cancer fatal. The use of herbal extracts of Tulsi, neem, and turmeric as a natural healer and safest antimicrobial provides better dental care treatment. In addition, aromatic agents like tulsi, neem, mint, clove, ginger, and turmeric as dental products have increase palatability for patients who have lost their taste buds with growing age and diseases. Method: The literature search was conducted in academics, Google scholar, PubMed, WHO, and Sci.org using keywords dentistry, antimicrobials, herbs for dental management, experimental findings, bacterial strains, oral health, and hygiene. Results: The beneficial results from using various antimicrobials containing herbs are gaining popularity throughout the world. Subsequently, it further suggested that antimicrobials and, herbal extracts maintains oral hygiene, reduces bacterial lichens, biofilm adhesion and helps in the management of oral infections, improves health. Conclusion: Screening of newer antimicrobial formulations like dentifrices, gargles, throat paints, mouthwashes, and mouth sprays containing cost-effective herbals for promoting healthcare and plays a pivotal role in developing herbal industries for dental care.

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Design, Characterization and Clinical Evaluation of Curcumin Dental Film for the Treatment of Periodontitis

Cited by 3 publications

References 28 publications

Oral nano‐curcumin on gingival inflammation in patients with gingivitis and mild periodontitis

Oral nano‐curcumin on gingival inflammation in patients with gingivitis and mild periodontitis

Periodontal Film: A Potential Treatment Strategy for Periodontitis

Impact of the Current Scenario and Future Perspectives for the Management of Oral Diseases: Remarkable Contribution of Herbs in Dentistry

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