Design, Characterization, Molecular Docking, and Insecticidal Activity of Some New Heterocyclic Compounds Containing Pyrazole Moiety against Spodoptera frugiperda (J.E. Smith) (Noctuidae: Lepidoptera)

El-Gaby, M. S. A.; Hussein, M. F.; Reheim, M. A. M. Abdel; Abdou, A.; Fahmy, A. M.; Drar, A. M.; Gad, M. A.

doi:10.1134/s106816202403018x

Russ J Bioorg Chem

2024

DOI: 10.1134/s106816202403018x

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Design, Characterization, Molecular Docking, and Insecticidal Activity of Some New Heterocyclic Compounds Containing Pyrazole Moiety against Spodoptera frugiperda (J.E. Smith) (Noctuidae: Lepidoptera)

M. S. A. El-Gaby,

M. F. Hussein,

M. A. M. Abdel Reheim

et al.

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Cited by 5 publications

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New Prospective Insecticidal Agents Based on N‐(arylcarbamothioyl)arylmide Derivatives Against Spodoptera frugiperda: Design, Synthesis, Toxicological, Biological, Biomedical Studies and Antibacterial Activity

Khalaf,

Abd El‐Lateef,

Gouda

et al. 2024

Chemistry & Biodiversity

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In this work, a novel series of N‐(arylcarbamothioyl)arylmide) 2–11 were synthesized by treating One‐Pot three‐multicomponent of Aroyl chloride ammonium isothiocyanate and amine compounds under refluxing conditions. Using spectroscopic methods, the chemical structure of the novelty developed compounds were investigated. After five days, the proposed derivatives' insecticidal bioassay was assessed using the median lethal concentration (LC50) against the second & fourth larvae of Spodoptera frugiperda as toxicity agents. The findings showed that, to varying degrees, every tested substance exerted insecticidal effects on S. frugiperda larvae in both of their instars. Compound 9 was the most poisonous of them all, having an LC50 against larvae in their second and fourth instars of 60.45 and 123.21 mg/L, respectively. Additionally, a few biological and biochemical characteristics of the substances that were generated in a lab setting were also looked at. Furthermore, this work discusses how to discover novel compounds that may one day be employed as insecticidal agents. Finally, all the designed components were monitored for their antibacterial effectiveness toward both Gram‐positive & Gram‐negative bacteria.

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New Prospective Insecticidal Agents Based on N‐(arylcarbamothioyl)arylmide Derivatives Against Spodoptera frugiperda: Design, Synthesis, Toxicological, Biological, Biomedical Studies and Antibacterial Activity

Khalaf,

Abd El‐Lateef,

Gouda

et al. 2024

Chemistry & Biodiversity

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Acyl Hydrazides as Insecticides: Synthesis, Biochemical, Structure‐Activity Relationship Studies and Insecticidal Activity of some IGRs Analogues Against Spodoptera littorallis (Boisd.)

Drar,

AL‐Saadi,

Thagfan

et al. 2024

Chemistry & Biodiversity

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The exponential rise in pesticide resistance to conventional chemical pesticides is another major factor driving the development of novel insecticidal active agents. One approach to solving this problem is to investigate novel classes and environmentally safe insecticidal chemicals with a variety of modes of action. Among these techniques is the creation of novel tebufenozide derivatives. Tebufenozide belongs to the insect growth regulator class of insecticides and is regarded as one of the safest chemical insecticides ever. The toxicological and biochemical efficiency of each analog was assessed against the Spodoptera littoralis pest in both its second and fourth instar larvae. The bioassay results show that compound 7 was the most effective insecticidal agent, with LC50 values of 10.6.5 and 18.7 mg/L against S. littoralis larvae in their second and fourth instar larvae, respectively. Finally, it was shown how treatment with the LC50 of the examined substances affected the activity of many enzymes involved in the cuticle production of S. littoralis larvae in their fourth instar. From this study, it was concluded that Acyl hydrazide are helpful for the management of S. littoralis and will be an effective replacement for other synthetic insecticides.

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Functionalized carbohydrazide: Synthesis, insecticide evaluation, biological and histological studies of some new carbohydrazide derivatives against Spodoptera frugiperda

Drar,

AL-Saadi,

Elhady

et al. 2024

Journal of the Indian Chemical Society

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Design, Characterization, Molecular Docking, and Insecticidal Activity of Some New Heterocyclic Compounds Containing Pyrazole Moiety against Spodoptera frugiperda (J.E. Smith) (Noctuidae: Lepidoptera)

Cited by 5 publications

References 68 publications

New Prospective Insecticidal Agents Based on N‐(arylcarbamothioyl)arylmide Derivatives Against Spodoptera frugiperda: Design, Synthesis, Toxicological, Biological, Biomedical Studies and Antibacterial Activity

New Prospective Insecticidal Agents Based on N‐(arylcarbamothioyl)arylmide Derivatives Against Spodoptera frugiperda: Design, Synthesis, Toxicological, Biological, Biomedical Studies and Antibacterial Activity

Acyl Hydrazides as Insecticides: Synthesis, Biochemical, Structure‐Activity Relationship Studies and Insecticidal Activity of some IGRs Analogues Against Spodoptera littorallis (Boisd.)

Functionalized carbohydrazide: Synthesis, insecticide evaluation, biological and histological studies of some new carbohydrazide derivatives against Spodoptera frugiperda

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