Design considerations for high-density fully intraocular epiretinal prostheses

Monge, Manuel; Emami, Azita

doi:10.1109/biocas.2014.6981703

Cited by 2 publications

(1 citation statement)

References 12 publications

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“…This is especially true with the epiretinal implants, as the electrode array is usually 20-50 µm away from the ganglion cell layer, separated by the saline. An Origami-like design of 3D spherical arrays that potentially yields better electrical contact, by maximizing array apposition to the retina, has been under investigation (Liu et al, 2013;Monge and Emami, 2014). Such a 3D array is constructed from a 2D parylene-C film with designed folding crease patterns.…”

Section: Acuity and Electrode-retina Contactmentioning

confidence: 99%

Retinal stimulation strategies to restore vision: Fundamentals and systems

Lan

Weiland

Roska

et al. 2016

Progress in Retinal and Eye Research

239

185

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Retinal degeneration, a leading cause of blindness worldwide, is primarily characterized by the dysfunctional/degenerated photoreceptors that impair the ability of the retina to detect light. Our group and others have shown that bioelectronic retinal implants restore useful visual input to those who have been blind for decades. This unprecedented approach of restoring sight demonstrates that patients can adapt to new visual input, and thereby opens up opportunities to not only improve this technology but also develop alternative retinal stimulation approaches. These future improvements or new technologies could have the potential of selectively stimulating specific cell classes in the inner retina, leading to improved visual resolution and color vision. In this review we will detail the progress of bioelectronic retinal implants and future devices in this genre as well as discuss other technologies such as optogenetics, chemical photoswitches, and ultrasound stimulation. We will discuss the principles, biological aspects, technology development, current status, clinical outcomes/prospects, and challenges for each approach. The review will cover functional imaging documented cortical responses to retinal stimulation in blind patients.

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Section: Acuity and Electrode-retina Contactmentioning

confidence: 99%

Retinal stimulation strategies to restore vision: Fundamentals and systems

Lan

Weiland

Roska

et al. 2016

Progress in Retinal and Eye Research

239

185

View full text Add to dashboard Cite

show abstract

A Three-Dimensional Microelectrode Array to Generate Virtual Electrodes for Epiretinal Prosthesis Based on a Modeling Study

Lyu

et al. 2020

Int. J. Neur. Syst.

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Despite many advances in the development of retinal prostheses, clinical reports show that current retinal prosthesis subjects can only perceive prosthetic vision with poor visual acuity. A possible approach for improving visual acuity is to produce virtual electrodes (VEs) through electric field modulation. Generating controllable and localized VEs is a crucial factor in effectively improving the perceptive resolution of the retinal prostheses. In this paper, we aimed to design a microelectrode array (MEA) that can produce converged and controllable VEs by current steering stimulation strategies. Through computational modeling, we designed a three-dimensional concentric ring–disc MEA and evaluated its performance with different stimulation strategies. Our simulation results showed that electrode–retina distance (ERD) and inter-electrode distance (IED) can dramatically affect the distribution of electric field. Also the converged VEs could be produced when the parameters of the three-dimensional MEA were appropriately set. VE sites can be controlled by manipulating the proportion of current on each adjacent electrode in a current steering group (CSG). In addition, spatial localization of electrical stimulation can be greatly improved under quasi-monopolar (QMP) stimulation. This study may provide support for future application of VEs in epiretinal prosthesis for potentially increasing the visual acuity of prosthetic vision.

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Design considerations for high-density fully intraocular epiretinal prostheses

Cited by 2 publications

References 12 publications

Retinal stimulation strategies to restore vision: Fundamentals and systems

Retinal stimulation strategies to restore vision: Fundamentals and systems

A Three-Dimensional Microelectrode Array to Generate Virtual Electrodes for Epiretinal Prosthesis Based on a Modeling Study

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