Design, Development and Evaluation of Thiocolchicoside and Famotidine Agglomerates by Crystallo Co-Agglomeration Technique

Bhamburkar, Sushant; Patharkar, Swanand

doi:10.52711/2231-5691.2022.00019

Cited by 3 publications

(1 citation statement)

References 10 publications

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“…Drug Content: In a 100 mL volumetric flask, 10 mg of agglomerates were accurately weighed and the volume was adjusted to 100 mL with methanol (100 g/mL), which served as a test solution. A UV spectrophotometer was used to analyse the standard solution after it had been sonicated for 5 minutes 8 .…”

Section: Characterization Of Favipiravir Crystallo-co-agglomeratesmentioning

confidence: 99%

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2023

IJPSR

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During the severe worldwide pandemic caused due to SARS COV-2 Corona virus, Favipiravir has been used for the treatment. It is a water insoluble anti-viral drug with poor dissolution and poor flow properties, resulting in poor oral absorption and less bioavailability. For a long time, the phrase "direct compression" was used to describe the compression of a single crystalline component into a compact without the addition of any other materials. Using excipients and solvents, the crystallo-co-agglomeration process aggregates drug crystals in the form of small spherical particles to create an intermediate product with better micromeritic and mechanical characteristics, solubility, and dissolution. Crystallo-co-agglomeration is a unique approach in which the pharmaceuticals or excipients are crystallized and agglomerated concurrently from a good solvent and/or bridging liquid by adding a nonsolvent. The present study aims to formulate crystallo-co-agglomerates of Favipiravir to improve its physicochemical and mechanical properties. Results obtained during the evaluation showed that CCA technique could be successfully employed as an alternative to conventional wet agglomeration.

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Section: Characterization Of Favipiravir Crystallo-co-agglomeratesmentioning

confidence: 99%

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2023

IJPSR

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Method Development using a UV Visible Spectrophotometer for the Simultaneous Estimation of Rabeprazole, Aceclofenac and Paracetamol in Marketed Formulation

Ahmad¹,

Jawed²

2023

AJPA

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Rheumatoid arthritis, or RA, is an autoimmune and inflammatory disease, which means that your immune system attacks healthy cells in your body by mistake, causing inflammation (painful swelling) in the affected parts of the body. RA mainly attacks the joints, usually many joints at once. A complexation, derivatization, extraction, evaporation and sensitive-free direct a new, simple, precise, accurate, reproducible, and efficient UV spectrophotometric method is developed and validated for the simultaneous estimation of ternary mixture of rabeprazole, (MET) aceclofenac (SXG) and paracetamol (DGF) in both their bulk form and combined in tablet dosage form recently approved by FDA in 2019 to be used for treatment of Type 2 diabetes mellitus by simultaneous equation method. The solutions of standard and sample were prepared in methanol: water (80:20 v/v). The 𝜆max for MET, SXG, and DGF were 232.0, 212.0 and 272.0nm, respectively. Calibration curves are linear in the concentration ranges 10-50𝜇g/ml for MET, 1-5𝜇g/ml for SXG and 5-25𝜇g/ml for DGF, respectively. Results of analysis of simultaneous equation method were analyzed and validated for various parameters according to ICH guidelines.

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IVF Modules of Management for Nurses and Clinical Practitioners which will help to add and keep track of Fertility Treatments

Ahmad¹,

Quazi²

2023

AJPT

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Infertility is a common problem that requires timely and sensitive intervention. The use of In-Vitro Fertilization (IVF) is now becoming a popular experience in developing countries. Infertility can be managed primarily by improving lifestyle, diet, exercise, and Couples should be advised of the importance of regular sexual intercourse every 2 or 3 days, regardless of the woman’s cycle. A drug like clomifene use in the primary treatment of infertility. Before and during the IVF nursing staff plays an important role in executes treatment plans that fertility doctors formulate with couples starting at the initial visit and also plays important role in supporting patients Psychologically. Some complications like multiple births, sex ratio distortions, and the spread of infectious diseases.

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Design, Development and Evaluation of Thiocolchicoside and Famotidine Agglomerates by Crystallo Co-Agglomeration Technique

Cited by 3 publications

References 10 publications

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Method Development using a UV Visible Spectrophotometer for the Simultaneous Estimation of Rabeprazole, Aceclofenac and Paracetamol in Marketed Formulation

IVF Modules of Management for Nurses and Clinical Practitioners which will help to add and keep track of Fertility Treatments

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