Design, Development and Evaluation of Diltiazem Hydrochloride Loaded Nanosponges for Oral Delivery

RAO, B. NARASIMHA; REDDY, K. RAVINDRA; FATHIMA, S. RAHATH; PREETHI, P.

doi:10.22159/ijcpr.2020v12i5.39784

Cited by 4 publications

(3 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The retention factor (Rf) value of a medicinal component decreases to a significant range in TLC, which aids in evaluating the development of complexes among nanosponges and the drug [59].…”

Section: Thin Layer Chromatography (Tlc)mentioning

confidence: 99%

Nanosponges: As a Dynamic Drug Delivery Approach for Targeted Delivery

Sharma¹,

Sharma

Gupta³

2023

Int J App Pharm

View full text Add to dashboard Cite

Recent advancements in nanotechnology have resulted in improved medicine delivery to the target site. Nanosponges are three-dimensional drug delivery systems that are nanoscale in size and created by cross-linking polymers. The introduction of Nanosponges has been a significant step toward overcoming issues such as drug toxicity, low bioavailability, and predictable medication release. Using a new way of nanotechnology, nanosponges, which are porous with small sponges (below one µm) flowing throughout the body, have demonstrated excellent results in delivering drugs. As a result, they reach the target place, attach to the skin's surface, and slowly release the medicine. Nanosponges can be used to encapsulate a wide range of medicines, including both hydrophilic and lipophilic pharmaceuticals. The medication delivery method using nanosponges is one of the most promising fields in pharmacy. It can be used as a biocatalyst carrier for vaccines, antibodies, enzymes, and proteins to be released. The existing study enlightens on the preparation method, evaluation, and prospective application in a medication delivery system and also focuses on patents filed in the field of nanosponges.

show abstract

Section: Thin Layer Chromatography (Tlc)mentioning

confidence: 99%

Nanosponges: As a Dynamic Drug Delivery Approach for Targeted Delivery

Sharma¹,

Sharma

Gupta³

2023

Int J App Pharm

View full text Add to dashboard Cite

show abstract

“…7.11, Serial Number: MAL1044595) [14]. For this, aqueous dispersions of nanosponges were diluted to an appropriate scattering intensity (100 µl of the dispersions diluted with 20 ml distilled water) [15].…”

Section: Measurement Of Particle Size Zeta Potential and Polydispersi...mentioning

confidence: 99%

Loxoprofen Nanosponges: Formulation, Characterization and Ex-Vivo Study

et al. 2022

View full text Add to dashboard Cite

Objective: The objective of this study is to optimize a nanosponge formulation for Loxoprofen and then incorporating it into a gel formulation offering a controlled drug release, enhanced skin permeation and thus better bioavailability. Methods: Loxoprofen nanosponges were prepared using the emulsion solvent diffusion method and formulated using Polyvinyl alcohol, Ethylcellulose and Dichloromethane. The effect of the different formulation variables like ethyl cellulose: polyvinyl alcohol ratio, drug: ethyl cellulose ratio, stirring time, stirring speed, internal phase volume and external phase volume on the particle size, entrapment efficiency, production yield, polydispersity index and Zeta potential was investigated. The optimized nanosponge formulation was incorporated into a gel. The loaded gel was evaluated by in vitro release and permeation studies and the results were compared to that of a marketed formulation (Loxonin® gel). Results: The optimized formulation showed 67.29±1.19 % entrapment efficiency, 239.8±16.95 nm particle size and-8.32±0.87 mV Zeta potential. The drug was released slowly from the nanosponge-loaded gel where the cumulative percentage of drug released was only 77.71±0.42 % in 8 h where it was incorporated in the entrapped form while it was 99.31±0.64% from Loxonin® gel where it was in the unentrapped form. The cumulative percent of drug permeated through the skin from the nanosponge-loaded gel was 98.66±0.14% for 24 h while it was only 60.38±0.18% from Loxonin® gel. Conclusion: The nanosponge-loaded gel showed more sustained drug release and a better drug permeation when compared to a marketed gel (Loxonin® gel).

show abstract

“…β-cyclodextrins (β-CDs) are cyclic oligosaccharides widely used in pharmaceutical and medical formulations [23,24]. The cross-linking of β-CDs, using an appropriate organic linker, leads to the formation of a β-CD nanosponge (βCDNSs), which can be described as polymers with a plethora of lipophilic and hydrophilic interstices, suitable for the inclusion of a broad spectrum of drugs [25][26][27][28][29].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Magnetite/Gold Core Shell Nanoparticles Stabilized with a β-Cyclodextrin Nanosponge to Develop a Magneto-Plasmonic System

et al. 2023

View full text Add to dashboard Cite

Magnetite/gold core-shell nanoparticles (magnetite/gold NPs) have important optical and magnetic properties that provide potential for applications, especially biomedical ones. However, their preparation is not exempt from difficulties that might lead to unexpected or undesired structures. This work reports the synthesis and characterization of magnetite/gold NPs using tetramethylammonium hydroxide (TMAH) to promote the formation of a continuous interface between the magnetite core and the thin gold shell. The synthesized magnetite/gold NPs were characterized using transmission electron microscopy (TEM), energy-dispersive spectroscopy (EDS), field emission scanning electron microscope (FE-SEM), ζ-potential, vibrating sample magnetometer (VSM), selected area electron diffraction (SAED), UV-Visible spectroscopy, and dynamic light scattering (DLS), confirming the core-shell structure of the NPs with narrow size distribution while evidencing its plasmonic and superparamagnetic properties as well. Further, the magnetite/gold NPs were associated and stabilized with a β-cyclodextrin nanosponge (β-CDNSs), obtaining a versatile magneto-plasmonic system for potential applications in the encapsulation and controlled release of drugs.

show abstract

Design, Development and Evaluation of Diltiazem Hydrochloride Loaded Nanosponges for Oral Delivery

Cited by 4 publications

References 7 publications

Nanosponges: As a Dynamic Drug Delivery Approach for Targeted Delivery

Nanosponges: As a Dynamic Drug Delivery Approach for Targeted Delivery

Loxoprofen Nanosponges: Formulation, Characterization and Ex-Vivo Study

Synthesis and Characterization of Magnetite/Gold Core Shell Nanoparticles Stabilized with a β-Cyclodextrin Nanosponge to Develop a Magneto-Plasmonic System

Contact Info

Product

Resources

About