Design expert assisted formulation, characterization and optimization of microemulsion based solid lipid nanoparticles of repaglinide

Maddiboyina, Balaji; Jhawat, Vikas; Nakkala, Ramya Krishna; Desu, Prasanna Kumar

doi:10.1007/s40204-021-00174-3

Cited by 14 publications

(7 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Starting from the leading-edge systems (ME 4, ME 8, and ME 10) characterized over the study, a numerical optimization was implemented to find microemulsions with reduced droplet size, moderate adhesion, and high diffusion coefficient. In this final stage, the parameters were fixed using constraints to achieve solutions with high desirability coefficients [ 124 ], as seen in Table 14 . The solutions obtained using the predictive tool of the software are presented in Figure 20 .…”

Section: Resultsmentioning

confidence: 99%

Development and Characterization of New Miconazole-Based Microemulsions for Buccal Delivery by Implementing a Full Factorial Design Modeling

Talianu,

Dinu-Pîrvu,

Ghica

et al. 2024

Pharmaceutics

View full text Add to dashboard Cite

This research aimed to develop miconazole-based microemulsions using oleic acid as a natural lipophilic phase and a stabilizer mixture comprising Tween 20 and PEG 400 to solubilize miconazole as an antifungal agent known for its activity in oral candidiasis and to improve its bioavailability. The formulation and preparation process was combined with a mathematical approach using a 23-full factorial plan. Fluid and gel-like microemulsions were obtained and analyzed considering pH, conductivity, and refractive index, followed by extensive analyses focused on droplet size, zeta potential, rheological behavior, and goniometry. In vitro release tests were performed to assess their biopharmaceutical characteristics. Independent variables coded X1-Oleic acid (%, w/w), X2-Tween 20 (%, w/w), and X3-PEG 400 (%, w/w) were analyzed in relationship with three main outputs like mean droplet size, work of adhesion, and diffusion coefficient by combining statistical tools with response surface methodology. The microemulsion containing miconazole base–2%, oleic acid–5%, Tween 20–40%, PEG 400–20%, and water–33% exhibited a mean droplet size of 119.6 nm, a work of adhesion of 71.98 mN/m, a diffusion coefficient of 2.11·10−5 cm2/s, and together with remarked attributes of two gel-like systems formulated with higher oil concentrations, modeled the final optimization step of microemulsions as potential systems for buccal delivery.

show abstract

Section: Resultsmentioning

confidence: 99%

Development and Characterization of New Miconazole-Based Microemulsions for Buccal Delivery by Implementing a Full Factorial Design Modeling

Talianu,

Dinu-Pîrvu,

Ghica

et al. 2024

Pharmaceutics

View full text Add to dashboard Cite

show abstract

“…It observed in Figure 3a, the value of ‘ t ‐value’ for ‘particle size’ was greater than the prescribed value of 12.7062; meanwhile, none of the factors crossed the ‘ t ‐value’ for ‘polydispersity index’. This indicated that TPGS have significant contribution in respect to particle size while developing the nanoparticles (Maddiboyina, Jhawat, Nakkala, et al, 2021).…”

Section: Resultsmentioning

confidence: 99%

Formulation, optimization and characterization of raloxifene hydrochloride loaded PLGA nanoparticles by using Taguchi design for breast cancer application

Maddiboyina¹,

Roy

Nakkala³

et al. 2023

Chem Biol Drug Des

Self Cite

View full text Add to dashboard Cite

Multidrug resistance in breast cancer and the associated side‐effects of anticancer therapies are significant hurdles in chemotherapy‐based treatment. Biodegradable polymeric nano‐based targeted drug delivery technologies showed tremendous advantages in targeted local delivery with limited off‐targeted side effects. Therefore, there is a persistent need to develop targeted nanomedicine systems for treatment of breast cancer. The current research attempted to develop poly (lactic‐co‐glycolic acid) nanoparticles loaded with raloxifene by modified emulsification solvent diffusion evaporation method to improve oral bioavailability by using Taguchi design. It was observed that the optimized formulation (1:4 drug to polymer ratio) poly (lactic‐co‐glycolic acid) showed a mean particle size and Polydispersity index of 218 ± 23.7 nm and 0.231 ± 0.04, respectively. The entrapment efficiency was found to be 82.30% ± 1.02%. In vitro drug delivery was found to be 92.5% ± 1.48% in 40 h. The nanoparticles were to remain stable at 2°C–8°C even after 30 days. Differential scanning calorimetry and Fourier transform infrared spectroscopy characterization techniques showed that there was no interaction between the drug and excipient. Stability studies indicate that polymeric nanoparticles were stable at 2°C–8°C after 6 months. Raloxifene nanoparticles may be the most potent targeting moieties to treat highly invasive and metastatic MCF‐7 breast cancer cells.

show abstract

“…The supernatant (1.0 ml) was diluted by methanol and the amount of Glibenclamide present in the supernatant was analyzed by uv vis spectrophotometer (UV-1700, Shimadzu corporation, Tokyo, Japan) against methanol as blank at 300 nm. The study was done in three times and their mean value was recorded 12 .…”

Section: Method: Screening Of Oil Surfactant and Cosurfactantmentioning

confidence: 99%

Untitled

2023

IJPSR

View full text Add to dashboard Cite

Uncontrolled diabetes is a major cause of blindness, kidney failure, heart attacks, stroke, and lower limb amputation. In 2019, diabetes was the ninth leading cause of death, with an estimated 1.5 million deaths directly caused by diabetes 1 . Sulphonylureas are a medicine used to enhance insulin release to control sugar levels in the normal range.Glibenclamide (Glb) is one of the most potent second-generation sulphonyurea (dose 2.5-20 mg) for it. Glb is highly lipophiic (pka-5.3) and BCS class II drug. This drug shows variable oral bioavailability due to poor drug solubility and dissolution. It also shows serious and sometimes fatal side effects like hypoglycemia attack and

show abstract

Design expert assisted formulation, characterization and optimization of microemulsion based solid lipid nanoparticles of repaglinide

Cited by 14 publications

References 18 publications

Development and Characterization of New Miconazole-Based Microemulsions for Buccal Delivery by Implementing a Full Factorial Design Modeling

Development and Characterization of New Miconazole-Based Microemulsions for Buccal Delivery by Implementing a Full Factorial Design Modeling

Formulation, optimization and characterization of raloxifene hydrochloride loaded PLGA nanoparticles by using Taguchi design for breast cancer application

Untitled

Contact Info

Product

Resources

About