Design, fabrication, characterisation and application of nanoelectrode arrays

Compton, Richard G.; Wildgoose, Gregory G.; Rees, Neil V.; Streeter, Ian; Baron, Ronan

doi:10.1016/j.cplett.2008.03.095

Cited by 125 publications

(107 citation statements)

References 99 publications

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“…The establishment of convergent diffusion is the most valuable peculiarity of microelectrodes, giving enhanced mass transport rates. This phenomenon results in a significant improvement of the analytical performance in terms of shorter response times, improved detection limits, increased sensitivity and decreased obstructing effects of solution resistance and convection [1] in comparison with macroelectrodes under planar diffusion. Low capacitive currents, due to the small surface area, contribute to higher signal-to-noise ratios.…”

Section: Introductionmentioning

confidence: 99%

Arrays of Screen‐Printed Graphite Microband Electrodes as a Versatile Electroanalysis Platform

et al. 2014

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Arrays of microband electrodes were developed by screen printing followed by cutting, which enabled the realization of microband arrays at the cut edge. Microband arrays of different designs were characterised with physical and electrochemical methods. In both cases the methods showed that the microband width was around 5 m. Semi-steady-state cyclic voltammetry responses were observed for redox probes.Chronocoulometric measurements showed the establishment of convergent diffusion regimes characterized by current densities similar to those of a single microelectrode.The analytical performance of the elaborated electrode system and its versatility were illustrated with two electrochemical assays: detection of ascorbic acid via direct oxidation and a mediated glucose biosensor fabricated via dip coating. Due to convergent mass transport both systems showed enhancement of the analytical characteristics. The developed approach can be adapted to automated electrode recovery.

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Section: Introductionmentioning

confidence: 99%

Arrays of Screen‐Printed Graphite Microband Electrodes as a Versatile Electroanalysis Platform

et al. 2014

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“…При модификации 1D структур золотыми наночастицами проявляется эффект синергизма за счёт перехода золотых наночастиц, обладающих высокой электрокаталитической активностью, в режим одномерности сопровождающийся переходом к пространственно-упорядоченным наноструктурам, обладающим пространственной анизотропией. Проблемой при работе с нанопроводами является получение "выровненных", то есть ориентированных строго в одном направлении, наноструктур [27]. Решением этой проблемы может быть включение магнитных сегментов, ковалентное связывание одномерных наноструктур с поверхностью сенсора, закрепление нанопроводов в каналах определённой матрицы.…”

Section: рисунокunclassified

Electrochemical sensor systems based on one dimensional (1D) nanostructures for analysis of bioaffinity interactions

et al. 2013

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It was shown that modification of screen printed graphite electrodes with gold nanoparticles (AuNPs) decorated Pb nanowires (PbNWs) demonstrates the enhancement of sensor’s analytical characteristics such as effective surface area, electro catalytic properties and heterogeneous electron transfer kinetics. The reason for such improvement may be the synergistic effect of AuNPs and PbNWs. Nanowires ensembles on electrode surface were employed for the detection of hemeproteins cytochrome P450 2B4, cytochrome c , and cardiac myoglobin in human plasma. Composite materials based on nanoparticles with different dimentions (3D three dimensional gold nanoparticles and 1D one dimensional Pb nanowires make it possible to construct biosensors with low detection limit of proteins.

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“…Комбинирование биораспознающего материала с наночастицами металлов для электрохимической регистрации аффинных взаимодействий -перспективное и быстроразвивающееся направление создания сенсоров. Наночастицы золота широко используются в качестве меток в "сэнвичевом" инверсионном анализе [23], так же как в качестве эффективного электрокатализатора для наноструктурирования поверхности электродов [16][17][18][19]. Поверхность золота может служить датчиком для детектирования биоаффинных взаимодействий [24,25].…”

Section: б аunclassified

“…Кроме того, биоэлектрохимические подходы позволяют миниатюризовать сенсорное устройство и в перспективе, иметь прототип "laboratory-on-a-chip" устройства [14,15]. Наночастицы металлов используются для формирования электродных покрытий, обеспечивающих благоприятное микроокружение для усиления прямого переноса электронов между редокс-активным белком и электродом [16][17][18][19].…”

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Electrochemical immunoanalysis of cardiac myoglobin

et al. 2010

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Method targeting the direct monitoring of myoglobin based on analysis of electrochemical parameters of modified electrodes were proposed. Method of direct detection is based on interaction of myoglobin with anti-myoglobin with subsequent electrochemical registration of hemeprotien. Myocardial infarction biomarker myoglobin was quantified at biological level using screen printed electrodes modified with gold nanoparticles stabilized with didodecyldimethylammonium bromide (DDAB) and antibodies. Proposed method did not require signal enhancement and amplification and also labeled secondary antibodies. Electro analysis has high specificity and sensitivity. Myoglobin -antibodies interaction was studied also with electrochemical impedance spectroscopy. Sensor has low detection limit and broad diapason of working concentrations (17.8 ng/ml - 1780 ng/ml; 1 nM - 10 nM). Method based on gold nanoparticles detection on the surface of electrodes was treated for myoglobin identification. AuNP worked as an electrochemical sensing platform: the oxidation of gold surface (resulted in gold oxide formation) upon polarization served as a basis for analytical response. The difference of cathodic peak area and peak high of gold oxide reduction in the case of electrodes with antibodies and electrodes with antibodies - myoglobin complex, was registered.

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Design, fabrication, characterisation and application of nanoelectrode arrays

Cited by 125 publications

References 99 publications

Arrays of Screen‐Printed Graphite Microband Electrodes as a Versatile Electroanalysis Platform

Arrays of Screen‐Printed Graphite Microband Electrodes as a Versatile Electroanalysis Platform

Electrochemical sensor systems based on one dimensional (1D) nanostructures for analysis of bioaffinity interactions

Electrochemical immunoanalysis of cardiac myoglobin

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