Design of a nanocarrier with regulated drug release ability utilizing a reversible conformational transition of a peptide, responsive to slight changes in pH

Murai, Kazuki; Higuchi, Masahiro; Kinoshita, Takatoshi; Nagata, Kenji; Kato, Katsuya

doi:10.1039/c3cp50916h

Cited by 20 publications

(17 citation statements)

References 24 publications

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“…Adenine DNA has been used as a capping agent taking advantage of the instability of the non-Watson–Crick secondary structures when the pH drops [ 205 ]. Double DNA strands formed by the interaction of thymine bases with Hg 2+ ions that suffer the phase transition to single strand when the pH drops have also been reported [ 206 ], as well as small peptides that suffer the β-sheet-to-random coil transition [ 207 ].…”

Section: Supramolecular Structures As Pore-capping Agentsmentioning

confidence: 99%

pH-Responsive Mesoporous Silica and Carbon Nanoparticles for Drug Delivery

2017

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The application of nanotechnology to medicine constitutes a major field of research nowadays. In particular, the use of mesoporous silica and carbon nanoparticles has attracted the attention of numerous researchers due to their unique properties, especially when applied to cancer treatment. Many strategies based on stimuli-responsive nanocarriers have been developed to control the drug release and avoid premature release. Here, we focus on the use of the subtle changes of pH between healthy and diseased areas along the body to trigger the release of the cargo. In this review, different approximations of pH-responsive systems are considered: those based on the use of the host-guest interactions between the nanocarriers and the drugs, those based on the hydrolysis of acid-labile bonds and those based on supramolecular structures acting as pore capping agents.

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Section: Supramolecular Structures As Pore-capping Agentsmentioning

confidence: 99%

pH-Responsive Mesoporous Silica and Carbon Nanoparticles for Drug Delivery

2017

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“…pH‐dependent conformational transition of peptides may be suitable for the mesopore cap–uncap switching behavior. As the proof of concept, Kato's group demonstrated that a DDS utilized the pH‐sensitive reversible conformational transition peptide (Ac‐(VKVS) 4 E‐NH 2 ) as the gatekeeper of MSN . The peptide of a β‐sheet structure under weakly basic conditions (pH 8.0) could transform to a random coil conformation under weakly acidic conditions (pH 6.0).…”

Section: Stimuli‐responsive Peptidesmentioning

confidence: 99%

Advances in Peptide Functionalization on Mesoporous Silica Nanoparticles for Controlled Drug Release

Dong

Zhang

2016

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115

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During the last decade, using versatile, promising, and fascinating mesoporous silica nanoparticles (MSNs) as site-specific and stimuli-responsive drug delivery systems (DDSs) has received concentrated research interest. As one of the most attractive surface modification units, peptides have inherent bioactivity, biodegradability and biocompatibility. Recent progresses in the utilization of versatile peptides for surface functionalization of MSNs to achieve cell-specific targeting, fluorescence imaging, and intracellular diagnosis and treatment of tumors are summarized in this review. The various functional peptides decorated on the MSNs are introduced and classified into three types, including targeting peptides, stimuli-responsive peptides and multifunctional chimeric peptides. The limitations and challenges of peptide modified MSNs and their potential applications are further discussed.

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“…Nanocarriers that are highly sensitive to surrounding conditions (pH, temperature, concentration of biomolecules in the affected area, among others)h ave been actively studied as a base for several medical research areas, such as regenerative medicine, [1][2][3] drug delivery, [4][5][6][7][8] and gene therapy. [9,10] Nanocarriers are especially important in the research for new drug delivery systems, with the aim of improving patients' quality of life and reducing ad rug's side effects.…”

Section: Introductionmentioning

confidence: 99%

Regulated Drug Release Abilities of Calcium Carbonate–Gelatin Hybrid Nanocarriers Fabricated via a Self‐Organizational Process

et al. 2017

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In this study, we investigated the drug-releasing behavior of a calcium carbonate (CaCO )-gelatin hybrid nanocarrier, fabricated through a single process using biomimetic mineralization. The organic scaffold (gelatin) of the fabricated nanocarrier is responsible for its capacity to load anionic drugs and for controlling the morphology of the inorganic matrix (CaCO ). We studied the drug-releasing properties of the nanocarrier by investigating the response of the CaCO matrix to acidic conditions. We found that under neutral conditions, drug release from the nanocarrier was inhibited, whereas under acidic conditions, the drug was efficiently released. Therefore, drug release from the nanocarrier is largely dependent on the surrounding pH.

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Design of a nanocarrier with regulated drug release ability utilizing a reversible conformational transition of a peptide, responsive to slight changes in pH

Cited by 20 publications

References 24 publications

pH-Responsive Mesoporous Silica and Carbon Nanoparticles for Drug Delivery

pH-Responsive Mesoporous Silica and Carbon Nanoparticles for Drug Delivery

Advances in Peptide Functionalization on Mesoporous Silica Nanoparticles for Controlled Drug Release

Regulated Drug Release Abilities of Calcium Carbonate–Gelatin Hybrid Nanocarriers Fabricated via a Self‐Organizational Process

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