Industry 4.0 designates the recent digital revolution in the industrial sector, evolving from the comprehensive networking and automation of all the productive areas. Equipment, machinery, materials and products permit to (i) distinguish dealing out environmental settings and current status via sensors; (ii) join them through fixed software; and (iii) progress production procedures in an exclusive method. Additionally, Industry 4.0 exposes new trials to enterprises, especially small and medium-sized enterprises (SMEs). Firms should advance approaches to (i) achieve chances of innovation and digitalization; (ii) expand their processes; and (iii) define innovative business models. Based on these premises, a well-organized political, legal and infrastructural outline is essential to build up a business having an Industry 4.0 approach. Though bigger firms can get ahead through innovation processes and predicting the potential digitalization risks for their business models, SMEs may be in trouble. The present editorial aims to offer relevant research outcomes that has been carried out on such a current and emblematic theme, offering new perspectives and opportunities especially for SMEs.