Design of self-processing antimicrobial peptides for plant protection

Powell, William A.; Catranis, Catharine M.; Maynard, Charles

doi:10.1046/j.1365-2672.2000.00782.x

Cited by 126 publications

(73 citation statements)

References 16 publications

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“…Four transgenic lines of U. americana were transformed with an antimicrobial peptide using Agrobacterium (Newhouse et al 2007). ESF39A inhibits the growth of multiple bacterial and fungal pathogens in vitro (Powell et al 2000). Although the peptide ESF39A produced by the transgenic elms inhibited in vitro growth of O. novoulmi, other tests performed with American elm sap showed a reduction in its antimicrobial activity.…”

Section: Use Of Genetic Engineering (Ge) In the Search For Resistant mentioning

confidence: 99%

Breeding and scientific advances in the fight against Dutch elm disease: Will they allow the use of elms in forest restoration?

et al. 2018

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Elms (Ulmus spp.) were once dominant trees in mixed broadleaf forests of many European territories, mainly distributed near rivers and streams or on floodplains. Since ancient times they have provided important services to humans, and several selected genotypes have been massively propagated and planted. Today elm populations are severely degraded due to the negative impact of human-induced changes in riparian ecosystems and the emergence of the highly aggressive Dutch elm disease pathogens. Despite the death of most large elm specimens, there is no evidence of genetic diversity loss in elm populations, probably due to their ability to resprout after disease. The recovery of elm populations from the remaining diversity should build from genomic tools that facilitate achievement of resistant elm clones. Research works to date have discerned the genetic diversity of elms and are well on the way to deciphering the genetic clues of elm resistance and pathogen virulence, key findings for addressing recovery of elm populations. Several tolerant clones suitable for use in urban and landscape planting have been obtained through traditional species hybridization with Asian elms, and various native clones have been selected and used in pilot forest restoration projects. Successful reintroduction of elms should also rely on a deeper understanding of elm ecology, in particular their resilience to abiotic and biotic disturbances. However, all these efforts would be in vain without the final acceptance of elm reintroduction by the social actors involved, making it necessary to evaluate and publicize the ecosystem services elms can provide for today's society.

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Section: Use Of Genetic Engineering (Ge) In the Search For Resistant mentioning

confidence: 99%

Breeding and scientific advances in the fight against Dutch elm disease: Will they allow the use of elms in forest restoration?

et al. 2018

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“…Hemolytic activity was studied using a previously reported method [14,15]. A blood sample was collected from a cow, and red blood cells (RBCs) were isolated for use.…”

Section: Evaluation Of Hemolytic Activitymentioning

confidence: 99%

Synthesis of 3-[4-(2-furoyl)-1-piperazinyl]-N- (substituted)propanamides as promising antibacterial agents with mild cytotoxicity

et al. 2018

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Purpose: To evaluate the antibacterial activity and cytotoxicity of a series of molecules with amalgamation of furoyl, piperazine and amide moieties. Methods: New derivatives, namely 3-[4-(2-furoyl)-1-piperazinyl]-N-(substituted)propanamides, were synthesized and evaluated for their antibacterial activity and toxicity to mammalian cells. The synthesis was initiated by treating different aryl/aralkyl amines (1a-u) with 3-bromopropionyl chloride (2) to obtain the solid electrophiles 3a-u, which were collected by filtration. Thereafter, and 2-furoyl-1-piperazine (4) at equimolar ratios were allowed to react in acetonitrile and in the presence of a base, K2CO3, to form the target compounds, 5a-u. Structural elucidation was carried out using EI-MS (electron impact mass spectrometry), IR (infrared) and 1H-NMR (proton nuclear magnetic resonance). The antibacterial activity of the synthesized compounds was evaluated against various bacterial strains. Furthermore, hemolysis was determined to assess cytotoxicity using bovine red blood cells. Results: Molecules 5g, 5a, 5p, 5g and 5i were found to be potent agents against S. aureus, S. typhi, P. 8.34 ± 0.55, 8.37 ± 0.12, 8.65 ± 0.57, 8.97 ± 0.12 and 9.24 ± 0.50 µM, compared to 7.80 ± 0.19, 7.45 ± 0.58, 7.14 ± 0.58, 7.16 ± 0.58 and 7.29 ± 0.90 aeruginosa, E. coli and B. subtilis with respective minimum inhibitory concentration (MIC) values of

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“…Hemolytic activity was performed according to Powell et al [15]. A blood sample was collected from a cow, and RBCs (red blood cells) were isolated.…”

Section: Hemolytic Activity Assaymentioning

confidence: 99%

Antimicrobial, hemolytic and thrombolytic activities of some new N-substituted-2-({5-[(1E,3E)F-4-(1,3-benzodioxol- 5-yl)-1,3-butadienyl]-1,3,4-oxadiazol-2-yl}sulfanyl) propanamides

Yasir¹,

Jahangir²,

Ur-Rehman³

et al. 2017

Trop. J. Pharm Res

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Design of self-processing antimicrobial peptides for plant protection

Cited by 126 publications

References 16 publications

Breeding and scientific advances in the fight against Dutch elm disease: Will they allow the use of elms in forest restoration?

Breeding and scientific advances in the fight against Dutch elm disease: Will they allow the use of elms in forest restoration?

Synthesis of 3-[4-(2-furoyl)-1-piperazinyl]-N- (substituted)propanamides as promising antibacterial agents with mild cytotoxicity

Antimicrobial, hemolytic and thrombolytic activities of some new N-substituted-2-({5-[(1E,3E)F-4-(1,3-benzodioxol- 5-yl)-1,3-butadienyl]-1,3,4-oxadiazol-2-yl}sulfanyl) propanamides

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