Design, Optimization and Evaluation of Intranasal Nanotherapeutic of Atypical Antipsychotic Drug

Abstract

Objective:The current study manifests the successful optimization and delivery of chitosan nanoparticles utilizing the nasal route to overcome inherent issues of ziprasidone hydrochloride, an atypical antipsychotic drug to curtail its bioavailability problems. Materials & Methods:Chitosan nanoparticles were prepared by ionic gelation technique and optimized using Box-Behnken design. In vitro drug release kinetics and ex vivo nasal permeation potential were determined. Results & Discussion:Chitosan nanoparticles exhibited a mean particle size of 153.8 ± 13.3 nm, a mean polydispersity index of 0.433 ± 0.15; an Entrapment Efficiency of 87.3 ± 3.62%, and a Drug loading capacity of 8.7 ± 0.25%. Transmission electron microscopy examinations revealed spherical particle size with uniform drug distribution. The physicochemical