Design, optimization, and operation of SMB chromatography in the production of enantiomerically pure pharmaceuticals

Strube, Jochen; Jupke, Andreas; Epping, Achim; Schmidt–Traub, H.; Schulte, Michael; Devant, Ralf M.

doi:10.1002/(sici)1520-636x(1999)11:5/6<440::aid-chir15>3.0.co;2-k

Cited by 39 publications

(9 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The use of ion‐exchange media for this separation was first described by Lefevre18 at Dow in 1962, and SMB technology was later employed to improve process productivity. More recently, a great deal of attention has been given to separation of specialty chemicals including therapeutic proteins and other biomolecules19–21 and chiral compounds 22–25. To facilitate evaluation of additional applications where SMB chromatography may provide a cost effective option and thus take full advantage of its potential, new methods are needed that allow rapid assessment of process feasibility and rapid specification of reliable designs where appropriate, and this is the focus of our work.…”

Section: Introductionmentioning

confidence: 99%

Noninflammatory breast carcinoma with skin involvement

Güth

Moch

Herberich

et al. 2004

Cancer

View full text Add to dashboard Cite

This article describes a systematic miniplant‐based approach to rapid development of simulated moving bed (SMB) chromatography applications. The methodology involves analysis of single‐column pulse tests to screen adsorbents and operating conditions and to determine initial values of profile advancement factors used to specify flow rates for an initial SMB miniplant experiment. A lumped‐parameter linear driving force rate‐based model is developed by fitting process data from a single miniplant run. The data are fit in a two‐step procedure involving initial determination of effective adsorption isotherm constants as best‐fit parameters with subsequent adjustment of calculated mass transfer coefficients to refine the data fit. The resulting simulation is used to guide further miniplant work and minimize experimental effort. The methodology is illustrated with miniplant data for a binary protein separation showing excellent agreement between model results and process data generated over a wide range of operating conditions. © 2009 American Institute of Chemical Engineers AIChE J, 2009

show abstract

Section: Introductionmentioning

confidence: 99%

Noninflammatory breast carcinoma with skin involvement

Güth

Moch

Herberich

et al. 2004

Cancer

View full text Add to dashboard Cite

show abstract

“…This is particularly true in chiral separation us-Ž . Ž ing simulated moving-bed SMB systems cf Strube et al, . 1999;Juza et al, 2000;Rekoske, 2001 where purities of the products are crucial and have to satisfy relatively narrow specifications.…”

Section: Introductionmentioning

confidence: 99%

Multiobjective optimization of SMB and varicol process for chiral separation

et al. 2002

View full text Add to dashboard Cite

“…Developments to reduce solvent use and increase productivity include the simulated moving bed (SMB) technology . Although highly complex, this technology offers advantages such as high throughput, easy automatization and high achievable purity …”

Section: Introductionmentioning

confidence: 99%

“…[28][29][30][31][32] Although highly complex, this technology offers advantages such as high throughput, easy automatization and high achievable purity. [33][34][35] Enantioselective liquid-liquid extraction (ELLE) has been reported to be a technique that requires much less solvent than chromatographic approaches (including SMB) and is easier to scale up, 36,37 though due to the limited number of stages that are economical, an intrinsic selectivity of at least 1.5 was suggested. 38 ELLE can be applied at all scales from milligram experiments in the lab to industrial bulk scale and offers high transport rates and high flexibility.…”

Section: Introductionmentioning

confidence: 99%

Enantioseparation with liquid membranes

Gössi

Riedl

Schuur

2017

J of Chemical Tech & Biotech

View full text Add to dashboard Cite

Chiral resolution of racemic products is a challenging and important task in the pharmaceutical, agrochemical, flavor, polymer and fragrances industries. One of the options for these challenging separations is to use liquid membranes. Although liquid membranes have been known for almost four decades and have been used for optical resolutions, no comprehensive review has been published about the use of this technology for enantioseparations. In this review, the various liquid membrane‐related technologies are described and compared, including bulk liquid membranes, emulsion liquid membranes, micelle‐extraction and micellar enhanced ultrafiltration, as well as supported liquid membranes. Next to technological advances, an overview of recent developments in chiral recognition chemistry in liquid–liquid equilibria is presented. The following extractant classes have recently been reported in conjunction with chiral separation: cyclodextrines, BINOL's, calixarenes, crown ethers, BINAP's, tartaric acids and ionic liquids. The use of two supported (non‐liquid) membranes with an inner loop of extract phase appears to be the most stable liquid membrane configuration, allowing for a large degree of freedom in operational conditions such as solvent to feed ratio. The library of solvents still needs broadening to make the technology more versatile and based on the variety of successes with catalytically active organometallic complexes, development of new chiral selector systems based on asymmetric catalysis literature is suggested for future selector screening studies. © 2017 Society of Chemical Industry

show abstract

Design, optimization, and operation of SMB chromatography in the production of enantiomerically pure pharmaceuticals

Cited by 39 publications

References 12 publications

Noninflammatory breast carcinoma with skin involvement

Noninflammatory breast carcinoma with skin involvement

Multiobjective optimization of SMB and varicol process for chiral separation

Enantioseparation with liquid membranes

Contact Info

Product

Resources

About