Design, Synthesis and anti‐Microbial Activity of 1H‐Pyrazole Carboxylates.

Abstract

Pyrazole derivatives R 0180Design, Synthesis and anti-Microbial Activity of 1H-Pyrazole Carboxylates. -Dinitrophenyl hydrazones of β-ketoesters, (I), upon treatment with the Vilsmeier reagent yield pyrazole carboxylate related microbicides (III). Following the same procedure, the formyl pyrazole carboxylate (V) is obtained. The pyrazoles are active towards both plant pathogenic fungal growth inhibition and bacterial inhibition. Among the eight compounds tested, (V) significantly inhibits most of the bacterial growth and exhibits highly significant anti-fungal activity against different fungi. The first X-ray crystal structure in the family of microbicidal pyrazole-4-carboxylates is presented, cf. (IIIg). -(SRIDHAR, R.; PERUMAL*, P. T.; ETTI, S.; SHANMU-GAM, G.; PONNUSWAMY, M. N.; PRABAVATHY, V. R.; MATHIVANAN, N.; Bioorg. Med.

Synthesis, characterization and molecular docking studies of novel 2-amino 3-cyano pyrano[2,3H]chrysin derivatives as potential antimicrobial agents

“…Agar-diffusion method (Sridhar et al, 2004;Patel et al, 2012) was used for the determination of the preliminary antibacterial and antifungal activity. Ciprofloxacin and itrazole were used as reference drugs for antibacterial and antifungal activity, respectively.…”

“…The plates were incubated at 37°C for 1-3 days. Antimicrobial activity was determined by measuring the diameter of the zone of inhibition surrounding microbial growth (Sridhar et al, 2004;Patel et al, 2012). Compounds that showed significant growth inhibition zones were further evaluated for their MICs.…”

An environmental friendly approach for the catalyst-free synthesis of highly substituted pyrazoles promoted by ultrasonic radiation

“…The chemistry of pyrazole derivatives has received considerable attention in the medical research due to the various biological and pharmacological properties such as antitumor [1], antimicrobial [2], anti-inflammatory [3], antiviral [4], antifungal [5], analgesic [6], and anti-hyperglycemic activity [7]. The pyrazole motif makes up the core structure of numerous biologically active compounds.…”

Pyrazole amino acids: hydrogen bonding directed conformations of 3-amino-1H-pyrazole-5-carboxylic acid residue

“…Among various pyrazole‐containing compounds, pyrazole‐carboxylates and aminopyrazoles constitute the most important groups. The pyrazoles‐carboxylates, both ester and amides, reveal broad spectrum of antibacterial , fungicidal , generally anti‐microbial , herbicidal , aracidal , insecticidal , anti‐inflammatory , and anticancer activities. Aminopyrazoles also reveal biological properties, such as anticancer or anticonvulsant activities.…”