Design, Synthesis, and Anticancer Activity of Amide Derivatives of Structurally Modified Combretastatin-A4

Synthesis, Antiproliferative Activity and Molecular Docking Studies of Novel Doubly Modified Colchicine Amides and Sulfonamides as Anticancer Agents

“…In addition, from the chemical point of view, such a change at position C10 allows obtaining compounds more resistant to acid hydrolysis [29,30,33]. We have decided to check various amide and sulfonamide moieties because they have long been valued for their rich biological and chemical profiles and have emerged as a promising class of compounds in drug discovery [37][38][39][40][41].…”

Synergistic effects of combined cisplatin and Clinacanthus nutans extract on triple negative breast cancer cells

“…In this investigation, we demonstrated that both MDA-MB-231 (a highly metastatic and poorly differentiated cell line) and MDA-MB-468 (a metastatic and less differentiated cell line) that represent a TNBC subtype, were sensitized towards cisplatin by supplementation with an ethanolic leaf extract of C. nutans known to be enriched with compounds possessing anticancer properties. 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 46 This sensitization can be proven via the achievement of a lower cisplatin IC 50 concentration by 50% upon the treatment of addition of MDA-MB-231 cells with C. nutans ( Figure 1 H). In addition, the metastatic potential of MDA-MB-231 cells was significantly inhibited by almost 50% when treated with 3.05 μg/mL cisplatin + 10 μg/mL C. nutans when compared to 3.05 μg/mL cisplatin treatment.…”

“…A total of 18 major bioactive compounds with potential anticancer properties were identified by ethanol extraction. 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 Of these, fatty acid derivatives (28.34%), carboxylic acid ester derivatives (26.68%), and glycoside derivatives (22.47%), were the major constituents of C. nutans leaf extract ( Table 4 ).…”