Design, synthesis, and anticonvulsant evaluation of some novel 1, 3 benzothiazol-2-yl hydrazones/acetohydrazones

A comprehensive review in current developments of benzothiazole-based molecules in medicinal chemistry

“…Benzothiazol-2-yl hydrazones showed the good anticonvulsant agents, especially compound (191), which showed 75% protection (3/4, 1.0 h) and 50% protection (2/4, 0.5 h) at a dose of 100 mg/kg in mice. The presence of 4-bromo phenyl in the 1,3-benzothiazol-2-yl acetohydrazones showed good activity [225]. BTA possessing acetamide derivatives showed better protection indices than carbothiomide linkage in MES and ScPTZ screen without any CNS depressant effect or neurotoxicity.…”

Helical Arrangement of 2-(4-hydroxy-3-methoxyphenyl)-Benzothiazole in Crystal Formation and Biological Evaluation on HeLa Cells

“…Benzothiazoles are a class of bicyclic compounds with a broad spectrum of biological applications such as neuroprotective effects [1,2], antimicrobial activity [3][4][5][6], antioxidant and radioprotective effects [7], anticonvulsant activity [8,9] and antitumor properties [10,11]. In particular, 2-(4-hydroxy-3-methoxyphenyl)-benzothiazole has been reported to be a tyrosinase inhibitor against hyperpigmentation [12].…”

Synthesis and antimicrobial evaluation of novel 1,3-thiazoles and unsymmetrical azines

“…Benzothiazoles are biologically interesting molecules and their chemistry is receiving considerable attention due to their anticonvulsant, [1] antiviral, [2] antibacterial [3], antimicrobial [4,5], and fungicidal activities [6,7]. They are also useful as anti-allergenic [8] and anti-inflammatory [9] agents.…”