Design, synthesis and bioassay of the emerging photo-responsive fungicides

Fu, Wen; Hu, Xinyue; Yuan, Qinglong; Xu, Zhiping; Cheng, Jiagao; Li, Zhong; Shao, Xusheng

doi:10.1016/j.cclet.2022.108064

Cited by 5 publications

(3 citation statements)

References 31 publications

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“…The bioassay tests were performed according to mycelium growth rate method used in our previous works. [29,[42][43]…”

Section: In-vitro Biological Activitymentioning

confidence: 99%

“…In-vivo protections of the irradiated and unirradiated NP-TBZ on plant leaves from being infected by R. solani, F. graminearum and S. cucurbitae were measured according to our previous methods. [29,42] TBZ and deionized water were used as positive group and blank control, respectively.…”

Section: In-vivo Biological Activitymentioning

confidence: 99%

“…[15][16] The PRPG-caged strategy in molecular design has been widely applied in fields of medicine, [17][18] biochemistry, [19][20] material science, [21][22] and super-resolution imaging. [23][24] In agriculture, photo-controlled release of abscisic acid, [25] auxin indoleacetic acid, [26] fipronil, [27][28] dinotefuran, [28] phenamacril [29] and carbendazim [30] were achieved by caging pesticide molecules with PRPGs. O-nitrobenzyl, [31] phydroxybenzoyl, [32] coumarins, [33] quinolines, [34] dipyrrole methylene derivatives [35] and anthraquinones [36] are typical PRPGs in photopharmacology.…”

Section: Introductionmentioning

confidence: 99%

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O‐nitrobenzyl Caged Molecule Enables Photo‐controlled Release of Thiabendazole

Fu,

Shao,

et al. 2024

ChemBioChem

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Pesticides are essential in agricultural development. Controlled‐release pesticides have attracted great attentions. Base on a principle of spatiotemporal selectivity, we extended the photoremovable protective group (PRPG) into agrochemical agents to achieve controllable release of active ingredients. Herein, we obtained NP‐TBZ by covalently linking o‐nitrobenzyl (NP) with thiabendazole (TBZ). Compound NP‐TBZ can be controlled to release TBZ in dependent to light. The irradiated and unirradiated NP‐TBZ showed significant differences on fungicidal activities both in vitro and in vivo. In addition, the irradiated NP‐TBZ displayed similar antifungal activities to the directly‐used TBZ, indicating a factual applicability in controllable release of TBZ. Furthermore, we explored the action mode and microcosmic variations by SEM analysis, and demonstrated that the irradiated NP‐TBZ retained a same action mode with TBZ against mycelia growth.

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“…The bioassay tests were performed according to mycelium growth rate method used in our previous works. [29,[42][43]…”

Section: In-vitro Biological Activitymentioning

confidence: 99%

Section: In-vivo Biological Activitymentioning

confidence: 99%