2018
DOI: 10.1016/j.arabjc.2016.06.007
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Design, synthesis and biological evaluation of new substituted 5-benzylideno-2-adamantylthiazol[3,2-b][1,2,4]triazol-6(5 H )ones. Pharmacophore models for antifungal activity

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Cited by 29 publications
(21 citation statements)
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“…Almost all the tested compounds showed antibacterial activity but on different levels and this activity was even better than that of Streptomycin against L. monocytogenes, and E. coli. [46] The results of the antimicrobial activity evaluations reveals that substances 2 exhibited maximum inhibitory activity against Pseudomonas aeruginosa with the inhibition zone at 6 to 13 mm. [39]…”
Section: Antimicrobial Activitymentioning
confidence: 97%
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“…Almost all the tested compounds showed antibacterial activity but on different levels and this activity was even better than that of Streptomycin against L. monocytogenes, and E. coli. [46] The results of the antimicrobial activity evaluations reveals that substances 2 exhibited maximum inhibitory activity against Pseudomonas aeruginosa with the inhibition zone at 6 to 13 mm. [39]…”
Section: Antimicrobial Activitymentioning
confidence: 97%
“…If (hetero)arylcarbaldehydes were added to the reaction mixture, various thiazolo [3,2-b] [1,2,4]triazole-6 (5H)-ones 3 with various 5-(het)arylidene substituents were formed (Scheme 2). [41][42][43][44][45][46] According to El-Sherief et al, [47] 5-phenyl-1,-2,4-triazole-3-thiol was treated with various cyanocompounds that contain the active methylene group in the boiling acetic acid in the presence of sulfuric acid. As a result, the corresponding 5-amino-2-phenyl- [1,3] thiazolo [3,2-b] [1,2,4]triazoles 4 were obtained in moderate yields (Scheme 3).…”
Section: Synthesis Of Thiazolo [32-b][124]triazole Derivativesmentioning
confidence: 99%
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“…The anti-inflammatory activity of the twenty five substituted 5-benzylideno-2adamantylthiazol [3,2-b] [1,2,4]triazol-6(5H)ones previously synthesized [42] was predicted using the PASS (Prediction of Activity Spectra for substances) program ( Table 1). Prediction was based on the comparison of structural characteristics of the compounds with that of known anti-inflammatory agents within a databank of 989,000 molecules.…”
Section: Prediction Of Anti-inflammatory Activity Of Designed Compoundsmentioning
confidence: 99%