Design, synthesis and biological evaluation of N-benzylaryl cinnamide derivatives as tubulin polymerization inhibitors capable of promoting YAP degradation with potent anti-gastric cancer activities

Design, synthesis and cytotoxic activity of molecular hybrids based on quinolin-8-yloxy and cinnamide hybrids and their apoptosis inducing property

“…22–26 Moreover, cinnamide moiety is commonly exploited as a potential pharmacologically active component in the construction of tubulin assembly inhibitors. 27…”

Design, Synthesis, and Biological Evaluation of Newly Synthesized Cinnamide-Fluorinated Containing Compounds as Bioactive Anticancer Agents

“…Cinnamide, also known as cinnamamide or cinnamic acid amide, has a wide distribution and application in the fields of natural products and medicinal chemistry with a wide range of pharmacological activities. , It is important to note that cinnamide-based derivatives could be used as a promising framework for the development of anticancer agents . Over the past few years, the anticancer activities of numerous cinnamide derivatives have been increasingly reported to show potent anticancer activities on targets such as mitochondria, tubulin polymerization, and so on. , Cinnamide is also frequently used as a potential pharmacological active fragment in the design of EGFR tyrosine kinase inhibitors . In addition, imidazolone and 1,2,4-triazinone derivatives were found to have anticancer activity against several human cancer cell lines. , …”

“… 24 Over the past few years, the anticancer activities of numerous cinnamide derivatives have been increasingly reported to show potent anticancer activities on targets such as mitochondria, tubulin polymerization, and so on. 25 , 26 Cinnamide is also frequently used as a potential pharmacological active fragment in the design of EGFR tyrosine kinase inhibitors. 27 In addition, imidazolone and 1,2,4-triazinone derivatives were found to have anticancer activity against several human cancer cell lines.…”