Design, synthesis and biological evaluation of chalconyl blended triazole allied organosilatranes as giardicidal and trichomonacidal agents

Singh, Gurjaspreet; Arora, Aanchal; Mangat, Satinderpal Singh; Rani, Sapna; Kaur, Harpreet; Goyal, Kapil; Sehgal, Rakesh; Maurya, Indresh Kumar; Tewari, Rupinder; Choquesillo-Lazarte, Duane; Sahoo, Subash Chandra; Kaur, Navneet

doi:10.1016/j.ejmech.2015.11.029

Cited by 55 publications

(19 citation statements)

References 77 publications

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“…Functionalization of silatranes with different groups in exocyclic position is an important trend as the resulting compounds retain the activities of silatranes as well as substituted groups …”

Section: New Silatranes and Their Analogsmentioning

confidence: 99%

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New atranes and similar ionic complexes. Synthesis, structure, properties

Адамович

2019

Applied Organom Chemis

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Section: New Silatranes and Their Analogsmentioning

confidence: 99%

“…3‐Aminopropylsilatrane represents a convenient building block for design of numerous new advanced materials and pharmacologically active compounds . On the other hand, aldehydes are known to react with primary amines to deliver imines which can also be employed as precursors of drugs including antitumor ones …”

Section: New Silatranes and Their Analogsmentioning

confidence: 99%

New atranes and similar ionic complexes. Synthesis, structure, properties

Адамович

2019

Applied Organom Chemis

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“…A unique feature of these silatrane molecules is the coordination bond between nitrogen and a silicon atom which reduces susceptibility to acid -base hydrolysis and hence imparts stability to the compounds. [13][14][15][16][17] In the present article, we have synthesized antipyrine blended azomethine based silatranes and considered the dynamic presentation of designed hybrid scrutinized as the receptor for various metal ion sensing. Now, with respect to the chemosensing potential of the receptor, the sensor exhibited selectivity, sensitivity, use of aqueous solution and low detection limit.…”

Section: Introductionmentioning

confidence: 99%

First Report on the Synthesis of Antipyrine Crowned Siloxy Framework: Optical Recognition of Fe²⁺and Hg²⁺Ions

Singh

Satija

Singh³

et al. 2020

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The present work explores the synthesis and characterization of antipyrine crowned Organosilatranes from a condensation reaction between antipyrine and amino silane followed by transesterification reaction with tripodal ligand. A highly selective chemosensor based on the prepared antipyrine crowned Organosilatrane exhibited remarkable selectivity and sensitivity towards Fe2+ and Hg2+ ions. The sensor binds to these ions at 1 : 1 stoichiometry and with high affinity as determined by Jobs plot and apparent from binding constant values of 4.05 ×105 M−1and 3.79 ×105 M−1 respectively. The structure of newly synthesized silanes and Organosilatranes were corroborated by numerous spectroscopic techniques.

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“…To focus on health research, there is an urgent need for alternative safe and effective multipurpose agents that can simultaneously prevent diarrhea, pregnancy and sexually transmitted infections …”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of microwave‐assisted biologically active triazole silanes

Singh

Satija

Singh

et al. 2019

Applied Organom Chemis

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The alliance of new drug, green technology and public health initiatives is essential for the ecosystem. The microwave technique is used to synthesize new drugs cognate to metronidazole. A new family of triethoxysilanes (3a–3e) was synthesized after reconnaissance with terminal alkynes (2a–2e) as an array using the Huisgen 1,3‐dipolar cycloaddition. All products were obtained in excellent yield with recovery of the catalyst as well as the solvent, and in a short time span. The design feature of these compounds is the tailoring of two unsymmetrical triazole nuclei into a single scaffold. The pharmacokinetic profiles of the triazole scaffold were analyzed using MOLINSPIRATION and ADMET toolkits, which gave promising results that prompted the investigation of these compounds for anti‐parasitic activity against parasites (Giardia lamblia and Trichomonas vaginalis) in contrast to standard drug (metronidazole). Compound 3d manifested good efficacy against both strains amongst all the synthesized triazole analogs. Highlights By using microwave methodology, a series of triazole functionalized alkynes and triazole organo silanes were synthesized. This involves tailoring of the 1,2,4‐triazole nucleus to 1,2,3‐triazole moiety. The protocol afforded excellent yield in a short time span under eco‐friendly conditions. The hybrid molecules were screened for their physicochemical properties using MOLINSPIRATION software and ADMET web server. All the synthesized compounds were investigated for their antioxidant activity, anti‐giardial and anti‐trichomonal activities. Tris triazole silane (3d) was found to be the most significant against Giardia lamblia and Trichomonas vaginalis, respectively, and this low‐price, versatile drug will hopefully lead to the eventual elimination of parasitic disease from the human population. Thermal gravimetric analysis has been performed for compounds (2a–2e) and (3a–3e).

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Design, synthesis and biological evaluation of chalconyl blended triazole allied organosilatranes as giardicidal and trichomonacidal agents

Cited by 55 publications

References 77 publications

New atranes and similar ionic complexes. Synthesis, structure, properties

New atranes and similar ionic complexes. Synthesis, structure, properties

First Report on the Synthesis of Antipyrine Crowned Siloxy Framework: Optical Recognition of Fe²⁺and Hg²⁺Ions

Synthesis and characterization of microwave‐assisted biologically active triazole silanes

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Design, synthesis and biological evaluation of chalconyl blended triazole allied organosilatranes as giardicidal and trichomonacidal agents

Cited by 55 publications

References 77 publications

New atranes and similar ionic complexes. Synthesis, structure, properties

New atranes and similar ionic complexes. Synthesis, structure, properties

First Report on the Synthesis of Antipyrine Crowned Siloxy Framework: Optical Recognition of Fe2+and Hg2+Ions

Synthesis and characterization of microwave‐assisted biologically active triazole silanes

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Product

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First Report on the Synthesis of Antipyrine Crowned Siloxy Framework: Optical Recognition of Fe²⁺and Hg²⁺Ions