Design, synthesis, and biological evaluation of substituted hydrazone and pyrazole derivatives as selective COX-2 inhibitors: Molecular docking study

Design, synthesis, characterization andin vitroandin vivoanti-inflammatory evaluation of novel pyrazole-based chalcones

“…Pyrazole are an important class of compounds for new drug development that attracted much attention due to their broad spectrum of biological activities, such as anti-inflammatory [9][10][11][12][13][14] , antifungal 15 , anticancer [16][17][18][19] , and antiviral activities 20,21 . Pyrazole derivatives also acting as anti-angiogenic agents 22 , A3 adenosine receptor antagonists 23 , neuropeptide YY5 receptor antagonists 24 , kinase inhibitor for the treatment of type 2 diabetes, hyperlipidemia, obesity 25 , and thrombopiotinmimetics 26 were reported.…”

4-Fluoro-N'-(2-hydroxy-3-methoxybenzylidene) benzohydrazide and its Oxidovanadium(V) Complex: Syntheses, Crystal Structures and Insulin-enhancing Activity

“…14,15 Schiff bases with hydrazone type are of particular interest due to their biological properties. [16][17][18][19][20] In recent years, a number of vanadium complexes were prepared from tridentate hydrazones, because of their excellent coordination ability and facilitate preparation. In view of the increasing importance of vanadium complexes with hydrazone type Schiff bases, we report herein the synthesis, characterization, and insulin-enhancing activity of a novel oxidovanadium(V) complex with the hydrazone compound 4-fluoro-N'-(2-hy-droxy-3-methoxybenzylidene)benzohydrazide monohydrate (H 2 L · H 2 O; Scheme 1) and maltol analogous compound kojic acid (5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one; Hka; Scheme 1).…”

N′-(3-Hydroxybenzylidene)-4-methylbenzohydrazide

“…For the biological activity of benzohydrazide compounds, see: El-Sayed et al (2011);Horiuchi et al (2009). For benzohydrazide coordination compounds, see: El-Dissouky et al (2010); Zhang et al (2010).…”

“…For standard bond lengths, see: Allen et al (1987) Table 1 Hydrogen-bond geometry (Å , ). Benzohydrazide compounds are well known for their biological activities (El-Sayed et al, 2011;Horiuchi et al, 2009). In addition, benzohydrazide compounds have also been used as versatile ligands in coordination chemistry (El-Dissouky et al, 2010, Zhang et al, 2010.…”