Design, synthesis and biological evaluation of small molecule fluorescent probes targeting EGFR for tumor detection and treatment

Abstract

Epidermal growth factor receptor (EGFR) is a tyrosine kinase receptor that plays a crucial role in cell differentiation and tumor progression, and its overexpression is closely associated with the development...

Improving nanochemoimmunotherapy efficacy by boosting “eat-me” signaling and downregulating “don't-eat-me” signaling with Ganoderma lucidum polysaccharide-based drug delivery

“…Previous reports demonstrated that gefitinib exhibits IC 50 values ranging from ten to tens of micromoles in diverse cell types including breast cancer cells (MCF-7, MDA-MB-231), colon cancer cells (HT-29, HCT-116, CT26), liver cancer (HepG2) and normal cells (HEK-293T). 72 Consistent with these findings, our experimental result also indicated a concentration-dependent inhibition on CT26 tumor cell growth by gefitinib, except at relatively low concentrations where it slightly promoted cell proliferation (Fig. S3A, ESI †).…”