Design, synthesis and comparative cytotoxic investigation of platinum(II) complexes with some derivatives of 5-methyl-5-(4-pyridyl)hydantoin

Bakalova, Adriana; Buyukliev, Rossen; Varbanov, Hristo P.; Momekov, Georgi

doi:10.1016/j.ica.2014.07.030

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Hydantoins As Ligands In Organometallic Complexes1

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Cited by 7 publications

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“…5-Methyl-5′-pyridinyl-hydantoin and its derivatives are widely used ligands for the preparation of platinum(II), palladium(II), − gold(III), and mercury(II) complexes. , Depending on the position of the hydantoin core on the pyridinyl ring, 5-methyl-5-pyridylhydantoin could adopt either monodentate or bidentate coordination behavior (Scheme ).…”

Section: Hydantoins As Ligands In Organometallic Complexesmentioning

confidence: 99%

Recent Advances in the Synthesis of Hydantoins: The State of the Art of a Valuable Scaffold

et al. 2017

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The review highlights the hydantoin syntheses presented from the point of view of the preparation methods. Novel synthetic routes to various hydantoin structures, the advances brought to the classical methods in the aim of producing more sustainable and environmentally friendly procedures for the preparation of these biomolecules, and a critical comparison of the different synthetic approaches developed in the last twelve years are also described. The review is composed of 95 schemes, 8 figures and 528 references for the last 12 years and includes the description of the hydantoin-based marketed drugs and clinical candidates.

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