Design, synthesis and cytotoxic activity of molecular hybrids based on quinolin-8-yloxy and cinnamide hybrids and their apoptosis inducing property

Abstract

A sequence of novel quinoline-8-yloxy and cinnamide hybrids has been synthesized and evaluated for in vitro cytotoxicity against HepG2 liver cancer cells.

Synthesis, characterization and biological research of novel 2-(quinoline-4-carbonyl)hydrazide-acrylamide hybrids as potential anticancer agents on MCF-7 breast carcinoma cells by targeting EGFR-TK

“…23 Furthermore, it is also evidenced from literature that quinoline moiety linked to acrylamide function with different substitution pattern possess a wide range of anticancer properties. 24 Many acrylamide containing derivatives were evaluated for their cytotoxic capacity via inhibition of EGFR-TK signalling. In addition, acrylamide-based anticancer agents showed great potential for the treatment of cancer by induction of cell cycle arrest, differentiation, and cellular apoptosis.…”