RSC Med. Chem.
 2024
DOI: 10.1039/d3md00589e
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Design, synthesis and evaluation of 2-phenylpyrimidine derivatives as novel antifungal agents targeting CYP51

Zixuan Gao,
Jiachen Zhang,
Kejian Li
et al.

Abstract: We designed and synthesised a series of novel CYP51 inhibitors. Three rounds of structural optimisation and modification obtained compound C6 which showed superior antifungal activity.

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