2021
DOI: 10.1021/acs.jafc.1c01804
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Design, Synthesis, and Herbicidal Activity of Thioether Containing 1,2,4-Triazole Schiff Bases as Transketolase Inhibitors

Abstract: Transketolase (TK) represents a potential target for novel herbicide development. To discover novel TK inhibitors with potency against resistant weeds, 36 thioether compounds containing 1,2,4-triazole Schiff bases were designed and synthesized for herbicidal activity evaluation. The results demonstrated that compounds 5av and 5aw provided excellent weed control with inhibition of over 90% against the tested weeds, even at concentrations as low as 100 mg/L in vitro. In addition, compounds 5av and 5aw exhibited … Show more

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Cited by 30 publications
(53 citation statements)
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“…Instruments and Reagents. 1 H and 13 C nuclear magnetic resonance (NMR) spectra were taken on a Varian 400 spectrometer using tetramethylsilane as an internal reference (in CDCl 3 or DMSOd 6 ). ESI-MS was performed using an Agilent G6300 ion Trap mass spectrometer, and signals were recorded in m/z.…”
Section: ■ Materials and Methodsmentioning
confidence: 99%
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“…Instruments and Reagents. 1 H and 13 C nuclear magnetic resonance (NMR) spectra were taken on a Varian 400 spectrometer using tetramethylsilane as an internal reference (in CDCl 3 or DMSOd 6 ). ESI-MS was performed using an Agilent G6300 ion Trap mass spectrometer, and signals were recorded in m/z.…”
Section: ■ Materials and Methodsmentioning
confidence: 99%
“…Weeds directly competed with crops for nutrients, moisture, and light, which can cause over 80% crop yield loss. 1,2 A lot of herbicides have been widely used in agricultural production for weed control, which greatly increased the crop production. 1,3,4 Target-based drug design (TBDD) has attracted great attention because of its numerous advantages, including high selectivity, high efficiency, and safety for nontarget organisms.…”
Section: ■ Introductionmentioning
confidence: 99%
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“…Heterocyclic compounds, particularly those containing nitrogen, play important roles in biologically active compounds. [11] 1,2,4-Triazoles, an important class of ve-membered heterocyclic compounds containing nitrogen, [12] were demonstrated to present versatile biological activities, such as antifungal, [13][14] antiviral, [15] herbicidal, [16] insecticidal, [17] DPP-4 inhibitory, [18] and anticancer [19] activities. Besides, the thioether linkage in bioactive molecules was thought to improve drug-likeness by lowering lipophilicity and acting as a favorable Hbond acceptor.…”
Section: Introductionmentioning
confidence: 99%