Design, synthesis, and pharmacological evaluation of novel and selective COX-2 inhibitors based on bumetanide scaffold

Ibrahim, Tarek S.; Salem, Ibrahim M.; Mostafa, Samia M.; El‐Sabbagh, Osama I.; ElKhamisi, Mohamed K.M.; Hegazy, Lamees; Elgendy, Bahaa

doi:10.1016/j.bioorg.2020.103878

Cited by 11 publications

(5 citation statements)

References 17 publications

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“…These compounds are selective on COX-2 with SI = 61.13 ( 11a ), 71.93 ( 11b ), and 115.82 ( 11c ). Based on in vitro and in vivo experiment results, compounds 11b and 11c exhibited the highest anti-inflammatory activities and lowest incidence of pepticulcer 26 .…”

Section: Recent Development In Anti-inflammatory Agentsmentioning

confidence: 99%

Small molecule compounds with good anti-inflammatory activity reported in the literature from 01/2009 to 05/2021: a review

Bian

Wu³

et al. 2021

Journal of Enzyme Inhibition and Medicinal Chemistry

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Inflammation and disease are closely related. Inflammation can induce various diseases, and diseases can promote inflammatory response, and two possibly induces each other in a bidirectional loop. Inflammation is usually treated using synthetic anti-inflammatory drugs which are associated with several adverse effects hence are not safe for long-term use. Therefore, there is need for anti-inflammatory drugs which are not only effective but also safe. Several researchers have devoted to the research and development of effective anti-inflammatory drugs with little or no side effects. In this review, we studied some small molecules with reported anti-inflammatory activities and hence potential sources of anti-inflammatory agents. The information was retrieved from relevant studies published between January 2019 and May, 2021 for review. This review study was aimed to provide relevant information towards the design and development of effective and safe anti-inflammation agents.

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Section: Recent Development In Anti-inflammatory Agentsmentioning

confidence: 99%

Small molecule compounds with good anti-inflammatory activity reported in the literature from 01/2009 to 05/2021: a review

Bian

Wu³

et al. 2021

Journal of Enzyme Inhibition and Medicinal Chemistry

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“…Benzenesulfonamide derivatives ( 14) with a bumetanide main scaffold bearing pyrazole and triazole moieties were reported by Ibrahim et al 76 to be selective COX-2 inhibitors with IC 50 = 0.17-4.79 μM (SI = 4.84-115.82) (Fig. 15).…”

Section: Rsc Medicinal Chemistry Reviewmentioning

confidence: 99%

Non-steroidal anti-inflammatory drugs: recent advances in the use of synthetic COX-2 inhibitors

et al. 2022

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“…In 2020, Ibrahim et al. 63 have reported several novel benzenesulfonamide analogs which aim to developed as COX-2 inhibitors. Structurally, bumetanide was used as a precursor to synthesized new analogues.…”

Section: Chemistry and Pharmacology Of Structurally Modified Cox-2 In...mentioning

confidence: 99%

Recent development on COX-2 inhibitors as promising anti-inflammatory agents: The past 10 years

Zhang

et al. 2022

Acta Pharmaceutica Sinica B

139

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Design, synthesis, and pharmacological evaluation of novel and selective COX-2 inhibitors based on bumetanide scaffold

Cited by 11 publications

References 17 publications

Small molecule compounds with good anti-inflammatory activity reported in the literature from 01/2009 to 05/2021: a review

Small molecule compounds with good anti-inflammatory activity reported in the literature from 01/2009 to 05/2021: a review

Non-steroidal anti-inflammatory drugs: recent advances in the use of synthetic COX-2 inhibitors

Recent development on COX-2 inhibitors as promising anti-inflammatory agents: The past 10 years

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